| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Recently, metabolic regulation by the transcription factor p53 has been shown to play an important role in suppressing cancer. This p53-mediated metabolic regulation requires appropriate control of the spatiotemporal activity of AMPK, which is one of the target molecules for cancer therapy. However, the mechanism of cancer suppression by the p53-AMPK axis has not been fully elucidated.
Although this study did not elucidate the mechanism of cancer suppression by the p53-AMPK axis, we succeeded in developing fundamental technologies necessary for future research development, such as the relationship between p53 and nutrient metabolism and improved visualization of the spatiotemporal activity dynamics of AMPK.
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