Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
In the endoplasmic reticulum (ER) secretory and membrane proteins are synthesized. During the synthesis, some proteins cannot fold properly. Such misfolded proteins are degraded via proteasome in the cytosol. In this study, I focus on how misfolded proteins are delivered from ER lumen to ER membrane and revealed the redundant roles of OS9 and XTP3B for substrate degradation.
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