| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In the budding yeast, which is widely used as a model of the research for aging, mother and daughter cells are asymmetrically divided and mother cells become aging in the progress of cell division. It has been known that asymmetry of cellular components between mother and daughter cells is related to aging process. Recent studies indicate that accumulation of asymmetry of difference in protein quality can affect the cellular aging. In this research, older proteins asymmetrically accumulated in mother cells in the progress of aging are analyzed with proteomic approach. It was shown that profile of accumulated older proteins is different among yeast strains having different life-span, indicating association of such type of asymmetry with cellular aging.
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