| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Many organisms show left-right asymmetrical morphology and functions in their external and internal structures and the formation of left-right asymmetry is essential for the normal development. The applicant has been studying the mechanism by which cell chirality (cellular left-right asymmetry) induces the left-right asymmetric morphology of internal organs in vivo using the Drosophila embryonic hindgut as a model system. We have shown that cell chirality causes left-right asymmetrical gut tube twisting through a novel cellular behavior "chiral cell sliding". In this study, RNA interference screening, ex vivo tissue culture, and ultra-resolution live imaging showed the mechanisms that induce cell chirality and sliding.
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