| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Teleost such as zebrafish have the unique outflow tract called as bulbus arteriosus, which is composed from smooth muscle and rich in elastin, whereas the outflow tract of many vertebrates is composed from myocardium. The previous study has indicated that the duplication and sub/neofunctionalization of elastin gene is critical for the formation of bulbus arteriosus. In this study, I focused on ltbp and fibulin which promote the elastin synthesis, and found that the expression patterns of these genes were identical to that of elastinb gene in zebrafish heart development. Moreover, I revealed that the expressions of these elastin-related genes in the outflow tract are regulated by TGFbeta signaling.
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