| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The present study aims to elucidate a molecular mechanism of mouse follicle selection. Most primordial follicles that have started growing die by apoptosis, and only the survived follicles are ovulated. Many investigators have studied about it, but the detail is still unclear. The present study was carried out using a hormone substance that is suggested to suppress follicle selection (apoptosis). The results suggest that production and secretion of estradiol 17b (E2) are regulated by Activin-A induced by FSH and that E2 is involved in apoptosis. Based on the results, we propose a model that apoptosis is controlled by E2.
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