| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
In order to identify novel genes involved in temperature signaling, genetic screening was performed using the phenotype of cold tolerance and acclimation in C. elegans. As a result, several molecules required for cold tolerance were isolated. Among them, the TRPV channels OSM-9 and OCR-2 also functioned as temperature receptors in the novel temperature-sensing neuron ADL. Furthermore, the DEG / ENaC type mechanoreceptor DEG-1 functioned as a temperature receptor in the novel temperature-sensing neuron ASG.
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