| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The male reproductive organ accessory gland in Drosophila produces components of seminal fluid. Excess nutrient signaling reduces fecundity through changes in gene expression that are mediated by inhibition of degradation of the transcriptional regulator Dve. Microarray analysis identified Dve target gene candidates.
In addition, a novel feedback mechanism is proposed that the strong stress induces accumulation of Dve proteins and suppresses the expression of the initial stress response genes (molecular chaperon, ER stress sensor Xbp1).
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