| Project/Area Number |
18K06353
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 45010:Genetics-related
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| Research Institution | Kamakura Women's University (2022-2023)
The University of Tokyo (2019-2021)
Chuo University (2018) |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 減数分裂期組換え / 染色体構造 / クロマチン / ヒストン |
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| Outline of Final Research Achievements |
To understand how meiotic recombination, a pivotal event for gametes production, occurs in chromatin structure, I have studied chromatin regulators such as a histone variant and a histone modifying enzyme as well as recombination initiation factors in fission yeast. This study revealed how a histone variant influences recombination products, how histone methyltransferase-related factors regulate initiation of recombination, and chromatin-binding kinetics of several recombination-related factors. These results along with recent knowledges obtained on other model organisms including mice, budding yeast, and plants, suggest both conserved and diverse aspects of meiotic recombination.
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| Academic Significance and Societal Importance of the Research Achievements |
減数分裂期組換えに関与する因子群は種を超えて保存されているが、各因子の個々の働きや因子間の相互作用の意義等は種ごとに異なる点が多い、分裂酵母を用いて本研究で得られた知見は、この現象の総合的理解の一助になると期待される。特に保存された染色体関連因子の機能について出芽酵母とマウスとの共通点や相違点の複数が明らかになったことは興味深い。減数分裂や騒動組換えが育種や遺伝子治療の基盤的な現象であることを考えると、今後の様々な生物における技術開発の助けになると思われる。
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