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Molecular basis of the acquisition of chordate traits: origin and evolution of chordates

Research Project

Project/Area Number 18K06370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45020:Evolutionary biology-related
Research InstitutionNational Institute for Basic Biology

Principal Investigator

Takahashi Hiroki  基礎生物学研究所, 分野横断研究ユニット, 助教 (40283585)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords脊索動物 / 脊索 / ホヤ / ナメクジウオ / ギボシムシ / ヒトデ
Outline of Final Research Achievements

The notochord is the central axis organ of the chordate system, and at the same time, it is the most important trait that characterizes chordates. Therefore, elucidating the molecular mechanism of notochord formation will lead to the elucidation of the chordate body plan and directly to the understanding of the mechanism of chordate evolution. Furthermore, elucidating how the common ancestor of the chordates, which did not have a notochord, acquired this novel trait will help us to understand the molecular basis of the birth of chordates, including humans. Therefore, we first clarified the molecular basis of the notochord trait in cephalochordates and urochordates, which are close to the ancestors of chordates. Next, we analyzed the molecular mechanism of notochord formation, and furthermore, aimed to elucidate the evolution of the notochord gene network.

Academic Significance and Societal Importance of the Research Achievements

脊索形成の分子メカニズムを明らかにすることは脊索動物の体制構築の解明につながると同時に、脊索動物進化のメカニズムの理解にも直結する。また、脊索を持たない共通祖先の動物がどのように、この新規形質を獲得したかをひも解くことは、 我々ヒトを含めた脊索動物誕生の分子的基盤を明らかにする事につながる。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (2 results)

  • [Int'l Joint Research] Xiamen University(中国)

    • Related Report
      2018 Research-status Report
  • [Journal Article] Enhancer activities of Amphioxus Brachyury genes in embryos of the ascidian, Ciona intestinalis2018

    • Author(s)
      Tominaga, H., Satoh, N., Ueno, N. & Takahashi, H.
    • Journal Title

      Genesis

      Volume: 56 Issue: 8

    • DOI

      10.1002/dvg.23240

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Enhancer activities of Amphioxus Brachyury genes in the ascidian ciona embryos2019

    • Author(s)
      Hitoshi Tominaga, Noriyuki Satoh, Naoto Ueno, Hiroki Takahashi
    • Organizer
      10th International Tunicate Meeting
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナメクジウオの二つのBrachyury遺伝子のエンハンサー機能解析2018

    • Author(s)
      冨永斉、佐藤矩行、上野直人、高橋弘樹
    • Organizer
      日本動物学会
    • Related Report
      2018 Research-status Report
  • [Remarks] 基礎生物学研究所 形態形成研究部門 形態形成の進化

    • URL

      https://www.nibb.ac.jp/morphgen/summary/lightbox/hoya.html

    • Related Report
      2019 Research-status Report
  • [Remarks] 基礎生物学研究所 形態形成研究部門 形態形成の進化

    • URL

      http://www.nibb.ac.jp/morphgen/summary/lightbox/hoya.html

    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2024-01-30  

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