| Project/Area Number |
18K06372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 45020:Evolutionary biology-related
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| Research Institution | Nara Women's University (2021)
Institute of Physical and Chemical Research (2018-2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
林 拓也 国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (50372115)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | パーソナリティ / 非ヒト霊長類 / fMRI / PET |
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| Outline of Final Research Achievements |
This study aims to relate personality of common marmosets, non-human primates, with genetic polymorphisms and neuroimaging involved in social behaviors. We revealed personality traits of common marmosets have five factors with two upper factors by a breeder's questionnaire evaluation, and investigated the association between personality scores and genetic polymorphisms of serotonin 1a receptors. PET images targeting the serotonergic and dopaminergic systems, high-resolution brain structural and resting functional MRI images were collected, and proceeded with the brain imaging analysis pipeline optimized for common marmosets referring to that for humans.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果は、個人を特徴づけている持続的で一貫した行動傾向であるパーソナリティが非ヒト霊長類にも同様に評価可能であり、その構造がヒトのパーソナリティ構造とよく似ていることを明らかにしたことである。脳画像の撮像とともに高精度の解析によって神経学的基盤の一端が明らかになれば、パーソナリティ研究の進化的考察とともに生物学的分野への拡充が進む。さらにヒトの個性と精神疾患との関連が議論される中、精神疾患の動物モデル研究に重要な示唆を与える。
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