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Clarify the mechanism that underlying the age-related decline of living standards

Research Project

Project/Area Number 18K06448
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45060:Applied anthropology-related
Research InstitutionNagasaki University

Principal Investigator

SHIMIZU Yuji  長崎大学, 医歯薬学総合研究科(医学系), 客員准教授 (40569068)

Co-Investigator(Kenkyū-buntansha) 前田 隆浩  長崎大学, 医歯薬学総合研究科(医学系), 教授 (40284674)
山梨 啓友  長崎大学, 病院(医学系), 講師 (60709864)
小屋松 淳  長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (90714212)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords筋力低下 / 血管リモデリング / 加齢性変化 / 高齢者 / 生活水準低下要因 / 動脈硬化 / 高血圧 / 歯周病 / 血管新生 / 器質的動脈硬化指標 / 機能的動脈硬化指標 / 造血能 / 末梢血造血幹細胞 / HTLV-1感染 / 筋力 / 生理的多型性
Outline of Final Research Achievements

Clarify the mechanism that underlying the age-related decline of living standards is our main purpose of present study. To establish this main purpose, we performed a survey of atherosclerosis and took blood sample in 2018 and 2019. The number of participants was 3,477. We also have 1,062 stocks of blood sample who were participating our survey in 2017. By using those samples, we measured angiopoitin-2 and analyzed genetic status (SNP). In addition to those data, we also used past data of our survey. By using those data, we performed multi-faceted analysis that clarify the many associations among reduced muscle strength, hypertension, atherosclerosis, habitual status, physiological and genetic status.

Academic Significance and Societal Importance of the Research Achievements

本研究により一部解明された、「高齢者における重大な生活水準低下要因の背景に存在する新たなネットワーク」は、効率的な生活水準低下予防戦略を立てる上で有用な新知見を提供することになり、医療経済学的効果や健康寿命延伸に大きく貢献する可能性を秘める。また、リスク評価機器の開発など新しい研究分野や産業分野の創設に繋がる可能性もあり意義深い。特に、造血能と血管修復能の関連に着目することで、日常診療で測定可能なヘモグロビン値などに新たな血管修復能予測因子としての役割を見出せる可能性があり、その社会的意義は大きく、今後の高齢化を迎える社会の問題解決に向けた汎用モデルに成り得る。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (34 results)

All 2021 2020 2019 2018

All Journal Article (23 results) (of which Peer Reviewed: 23 results,  Open Access: 23 results) Presentation (11 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Possible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population.2021

    • Author(s)
      Yuji Shimizu, Kazuhiko Arima, Yuko Noguchi, Shin-Ya Kawashiri, Hirotomo Yamanashi, Mami Tamai, Yasuhiro Nagata, Takahiro Maeda
    • Journal Title

      Environ Health Prev Med

      Volume: 26 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12199-021-00938-0

    • NAID

      210000158825

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between serum sodium level within normal range and handgrip strength in relation to hypertension status: a cross-sectional study.2021

    • Author(s)
      Yuji Shimizu, Hirotomo Yamanashi, Shoichi Fukui, Shin-Ya Kawashiri, Yasuhiro Nagata, Takahiro Maeda
    • Journal Title

      Sci Rep

      Volume: 11 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-020-80163-x

    • NAID

      120006956184

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Contribution of VEGF polymorphism rs3025020 to short stature and hypertension in elderly Japanese individuals: a cross-sectional study.2021

    • Author(s)
      Yuji Shimizu, Hirotomo Yamanashi, Shin-Ya Kawashiri, Kenichi Nobusue, Fumiaki Nonaka, Yuko Noguchi, Yukiko Honda, Kazuhiko Arima, Yasuyo Abe, Yasuhiro Nagata, Takahiro Maeda
    • Journal Title

      J Physiol Anthropol.

      Volume: 40 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s40101-021-00253-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of height on endothelial maintenance activity: a narrative review2021

    • Author(s)
      Shimizu Yuji、Maeda Takahiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 26 Issue: 1

    • DOI

      10.1186/s12199-021-00941-5

    • NAID

      210000159268

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin-Like Growth Factor-1 (IGF-1) and reduced tongue pressure in relation to atherosclerosis among community-dwelling elderly Japanese men: a cross-sectional study.2020

    • Author(s)
      Shimizu Yuji, Yamanashi Hirotomo, Noguchi Yuko, Koyamatsu Jun, Higashi Miho, Fukui Shoichi, Kawashiri Sin-Ya, Arima Kazuhiko, Takamura Noboru, Maeda Takahiro.
    • Journal Title

      Dysphagia

      Volume: - Issue: 6 Pages: 1-7

    • DOI

      10.1007/s00455-020-10096-0

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating CD34+ cells and active arterial wall thickening among elderly men: a prospective study2020

    • Author(s)
      Shimizu Y, Kawashiri SY, Kiyoura K, Koyamatsu J, Fukui S, Tamai M, Nobusue K, Yamanashi H, Nagata Y, Maeda T
    • Journal Title

      Scientific Reports

      Volume: 10

    • NAID

      120006988260

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential mechanisms underlying the association between single nucleotide polymorphism (BRAP and ALDH2) and hypertension among elderly Japanese population.2020

    • Author(s)
      Yuji Shimizu, Kazuhiko Arima, Yuko Noguchi, Shin-Ya Kawashiri, Hirotomo Yamanashi, Mami Tamai, Yasuhiro Nagata, Takahiro Maeda
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-020-71031-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-thyroid peroxidase antibody and thyroid cysts among the general Japanese population: a cross-sectional study.2020

    • Author(s)
      Shimizu Y, Nabeshima-Kimura Y, Kawashiri SY, Noguchi Y, Nagata Y, Maeda T, Hayashida N
    • Journal Title

      Environ Health Prev Med.

      Volume: 25 Issue: 1 Pages: 1-5

    • DOI

      10.1186/s12199-020-00844-x

    • NAID

      50014371181

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Normal range of anti-thyroid peroxidase antibody (TPO-Ab) and atherosclerosis among eu-thyroid population: A cross-sectional study.2020

    • Author(s)
      Yuji Shimizu, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
    • Journal Title

      Medicine (Baltimore)

      Volume: 99 Issue: 38 Pages: 1-5

    • DOI

      10.1097/md.0000000000022214

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-thyroid peroxidase antibody and subclinical hypothyroidism in relation to hypertension and thyroid cysts.2020

    • Author(s)
      Yuji Shimizu , Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
    • Journal Title

      PLoS One

      Volume: 15 Issue: 10 Pages: 1-10

    • DOI

      10.1371/journal.pone.0240198

    • NAID

      120006988494

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study.2020

    • Author(s)
      Yuji Shimizu, Yuko Nabeshima-Kimura, Shin-Ya Kawashiri, Yuko Noguchi, Yasuhiro Nagata, Takahiro Maeda, Naomi Hayashida
    • Journal Title

      Environ Health Prev Med.

      Volume: 25 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s12199-020-00910-4

    • NAID

      210000158632

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating CD34+ cells and active arterial wall thickening among elderly men: A prospective study2020

    • Author(s)
      Shimizu Yuji、Kawashiri Shin-Ya、Kiyoura Kairi、Koyamatsu Jun、Fukui Shoichi、Tamai Mami、Nobusue Kenichi、Yamanashi Hirotomo、Nagata Yasuhiro、Maeda Takahiro
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-9

    • DOI

      10.1038/s41598-020-61475-4

    • NAID

      120006988260

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between human T cell leukemia virus type-1 (HTLV-1) infection and advanced periodontitis in relation to atherosclerosis among elderly Japanese: a cross-sectional study2019

    • Author(s)
      Shimizu Yuji、Yamanashi Hirotomo、Kitamura Masayasu、Furugen Reiko、Iwasaki Takahiro、Fukuda Hideki、Hayashida Hideaki、Kawasaki Koji、Kiyoura Kairi、Kawashiri Shin-Ya、Saito Toshiyuki、Kawakami Atsushi、Maeda Takahiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 24 Issue: 1 Pages: 1-9

    • DOI

      10.1186/s12199-019-0836-2

    • NAID

      50014276987

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gamma-glutamyl transpeptidase (γ-GTP) has an ambivalent association with hypertension and atherosclerosis among elderly Japanese men: a cross-sectional study2019

    • Author(s)
      Shimizu Yuji、Kawashiri Shin-Ya、Kiyoura Kairi、Nobusue Kenichi、Yamanashi Hirotomo、Nagata Yasuhiro、Maeda Takahiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 24 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s12199-019-0828-2

    • NAID

      210000157729

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study2019

    • Author(s)
      Shimizu Yuji、Yamanashi Hirotomo、Kitamura Masayasu、Furugen Reiko、Iwasaki Takahiro、Fukuda Hideki、Hayashida Hideaki、Kawasaki Koji、Kiyoura Kairi、Kawashiri Shin-Ya、Saito Toshiyuki、Kawakami Atsushi、Maeda Takahiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 24 Issue: 1 Pages: 1-7

    • DOI

      10.1186/s12199-019-0796-6

    • NAID

      120006987690

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Short stature-related single-nucleotide polymorphism (SNP) activates endothelial repair activity in elderly Japanese2019

    • Author(s)
      Shimizu Yuji、Yamanashi Hirotomo、Noguchi Yuko、Koyamatsu Jun、Nagayoshi Mako、Kiyoura Kairi、Fukui Shoichi、Tamai Mami、Kawashiri Shin-Ya、Arima Kazuhiko、Maeda Takahiro
    • Journal Title

      Environmental Health and Preventive Medicine

      Volume: 24 Issue: 1 Pages: 1-8

    • DOI

      10.1186/s12199-019-0780-1

    • NAID

      210000155879

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between chronic kidney disease and carotid intima-media thickness in relation to circulating CD34-positive cell count among community-dwelling elderly Japanese men2019

    • Author(s)
      Shimizu Yuji、Yamanashi Hirotomo、Noguchi Yuko、Koyamatsu Jun、Nagayoshi Mako、Kiyoura Kairi、Fukui Shoichi、Tamai Mami、Kawashiri Shin-Ya、Kondo Hideaki、Maeda Takahiro
    • Journal Title

      Atherosclerosis

      Volume: 283 Pages: 85-91

    • DOI

      10.1016/j.atherosclerosis.2019.02.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between alkaline phosphatase and hypertension in relation to circulating CD34-positive cell levels pertaining to elderly Japanese men2019

    • Author(s)
      Matsubara Hiroshi, Yamanashi Hirotomo, Nagura Yuki, Kiyoura Kairi, Yoda Aya, Kondo Hideaki, Nakamichi Seiko, Maeda Takahiro, Shimizu Yuji.
    • Journal Title

      Acta Medica Nagasakienshia

      Volume: 62 Pages: 87-93

    • NAID

      130007683967

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardio‐ankle vascular index and circulating CD34‐positive cell levels as indicators of endothelial repair activity in older Japanese men2019

    • Author(s)
      Shimizu Yuji、Yamanashi Hirotomo、Noguchi Yuko、Koyamatsu Jun、Nagayoshi Mako、Kiyoura Kairi、Fukui Shoichi、Tamai Mami、Kawashiri Shin‐Ya、Kondo Hideaki、Maeda Takahiro
    • Journal Title

      Geriatrics & Gerontology International

      Volume: 印刷中 Issue: 6 Pages: 1-6

    • DOI

      10.1111/ggi.13657

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between height and circulating CD34-positive cells taken into account for the influence of enhanced production among elderly Japanese men: a cross-sectional study2019

    • Author(s)
      Shimizu Yuji、Yamanashi Hirotomo、Noguchi Yuko、Koyamatsu Jun、Nagayoshi Mako、Kiyoura Kairi、Fukui Shoichi、Tamai Mami、Kawashiri Shin-Ya、Arima Kazuhiko、Maeda Takahiro
    • Journal Title

      Aging

      Volume: 11 Issue: 2 Pages: 663-672

    • DOI

      10.18632/aging.101768

    • NAID

      120006987813

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reticulocyte levels have an ambivalent association with hypertension and atherosclerosis in the elderly: a cross-sectional study2019

    • Author(s)
      Shimizu Yuji, Kawashiri Shin-Ya, Yamanashi Hirotomo, Jun Koyamatsu, Shoichi Fukui, Hiideaki Kondo, Mami Tamai, Seiko Nakamichi, Takahiro Maeda.
    • Journal Title

      Clinical Interventions in Aging

      Volume: 印刷中 Pages: 849-857

    • DOI

      10.2147/cia.s197982

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single nucleotide polymorphism as an indicator of short stature and dyslipidemia in community-dwelling elderly Japanese subjects2018

    • Author(s)
      Tezuka Kazuhide, Shimizu Yuji, Noguchi Yuko, Sato Shimpei, Koyamatsu Jun, Yamanashi Hirotomo, Nagayoshi Mako, Kawashiri Shin-Ya, Nagata Yasuhiro, Maeda Takahiro.
    • Journal Title

      Acta Medica Nagasakienshia

      Volume: 62 Pages: 7-14

    • NAID

      130007683988

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced tongue pressure and platelet count in relation to hypertension among community dwelling elderly Japanese subjects2018

    • Author(s)
      Torii Kazuhiro, Shimizu Yuji, Sato Shimpei, Noguchi Yuko, Koyamatsu Jun, Yamanashi Hirotomo, Higashi Miho, Kawashiri Shin-Ya, Nakamichi Seiko, Takamura Noboru, Maeda Takahiro, Yanagihara Katsunori, Ozono Yoshiyuki
    • Journal Title

      Acta Medica Nagasakienshia

      Volume: 62 Pages: 27-34

    • NAID

      130007683944

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 甲状腺機能正常者におけるHbA1Cと甲状腺嚢胞の関係2021

    • Author(s)
      清水悠路、川尻慎也、野口優子、永田康浩、前田隆浩、林田直美
    • Organizer
      第91回日本衛生学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高齢男性における血管修復能を考慮した握力と高血圧の関係2020

    • Author(s)
      清水悠路、川尻慎也、北村雅保、小屋克淳、山梨啓友、福井翔一、近藤英明、福田英輝、斎藤俊行、前田隆浩
    • Organizer
      第90回日本衛生学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 甲状腺嚢胞の影響を考慮した潜在性甲状腺機能低下症と高血圧の関係2020

    • Author(s)
      清水悠路、小屋松淳、玉井慎美、有馬和彦、青柳潔、前田隆浩、林田直美
    • Organizer
      第79回日本公衆衛生学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] VEGF 一塩基多型(rs3025020)と高血圧の関係2020

    • Author(s)
      清水悠路、安部恵代、有馬和彦、野口優子、小屋松淳、山梨啓友、川尻慎也、前田隆浩
    • Organizer
      第81回日本生理人類学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Atherosclerosis as an adaptation for age-related physical changes.2020

    • Author(s)
      Shimizu Yuji
    • Organizer
      Nagasaki Leiden university joint symposium “The Clinical Science of on Healthy Ageing”
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 血管修復能を考慮した握力と高血圧の関係2020

    • Author(s)
      清水悠路、小屋松淳、山梨啓友、福井翔一、近藤英明、前田隆浩
    • Organizer
      第90回日本衛生学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 動脈硬化関連一塩基多型(rs3782886)と低身長の関係2019

    • Author(s)
      清水悠路、有馬和彦、野口優子、小屋松淳、山梨啓友、川尻真也、前田隆浩
    • Organizer
      第80回日本生理人類学会
    • Related Report
      2019 Research-status Report
  • [Presentation] 造血能を考慮した動脈硬化と高血圧の関係2019

    • Author(s)
      清水悠路、小屋松淳、山梨啓友、玉井慎美、有馬和彦、青柳潔、前田隆浩
    • Organizer
      第78回日本公衆衛生学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Preferred factional potential of atherosclerosis2019

    • Author(s)
      Shimizu Y, Kawashiri SY, Kiyoura K, Koyamatsu J, Fukui S, Tamai M, Nobusue K, Yamanashi H, Nagata Y, Maeda T.
    • Organizer
      14th International Congress of Physiological Anthropology
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高齢者における造血能の影響を考慮したエリスロポイエチンと歯周病の関係2019

    • Author(s)
      清水悠路、小屋松淳、山梨啓友、福井翔一、近藤英明、前田隆浩
    • Organizer
      第89回日本衛生学会
    • Related Report
      2018 Research-status Report
  • [Presentation] 高齢日本人男性における血管リモデリングと身長の関係2018

    • Author(s)
      清水悠路、小屋松淳、山梨啓友、川尻真也、玉井慎美、前田隆浩
    • Organizer
      第77回日本公衆衛生学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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