| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Given polyQ length variation brings human individuality according to the polyQ-diversified hypothesis, what is the biological basis? I speculated that polyQs functioned as scaffoldings of protein complexes by using binding ability of polyQ molecules. Thus, I analyzed protein-protein interaction information of proteins containing polyQs responsible for polyQ diseases and representatives of polyQ-binding proteins.
As a result, each of these proteins was suggested to involve formation of protein complexes and signal transduction in regulation of brain development.
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