| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Glaucoma causes vision loss due to progressive degeneration of retinal ganglion cells, but its pathological basis remains unclear. Glaucoma is considered as a neurodegenerative disease and endoplasmic reticulum stress response has been known as important regulator of neurodegenerative diseases. We focused on the ATF6 pathway, one of the three major axes of endoplasmic reticulum stress response, and elucidated its importance and molecular mechanisms in retinal neurodegeneration. Our results suggest that the ATF6 pathway induced after optic nerve injury plays a neuroprotective role by regulating glial cell function rather than retinal ganglion cells.
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