| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Cerebral infarction is an extremely common disease. This study analyzed the endogenous neuroprotective mechanism activated by cerebral infarction. We found that the transcription factor Npas4, which is known to promote neuronal development in a healthy brain, is strongly induced in cerebral cortical neurons after infarction. Analysis using Npas4-deficient mice and adeno-associated virus revealed that Npas4 plays a role in suppressing cell death in infarct lesions and maintaining prognostic motor function. Npas4 expression was induced by abnormal Ca2+ influx into ischemic neurons. Npas4 reduces Ca2+ influx and facilitates cell survival after infarction. These results suggest that Npas4 acts as a negative regulator of Ca2+ influx in ischemic neurons.
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