| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the molecular mechanism inducing expression of receptor tyrosine kinase Ror2 and its role in reactive astrocytes in the injured brain. We revealed that E2F1 plays an important role in regulating transcriptional induction of Ror2. We also found that Ror2 promotes the nuclear accumulation of Nrf2 and promotes oxidative stress tolerance. Our findings suggest that induced expression of Ror2 in reactive astrocytes plays an important role in promoting tissue repair following injury, and constitutive expression of Ror2 due to its regulatory disruption might contribute to the malignant progression of astrocytomas.
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