| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The cell biological mechanism of plastic changes in the peri-injured area during recovery after cortical injury is still unknown. The aim of this study is to determine the timing of synaptic delivery of AMPA receptors after cortical injury during recovery and the neurons responsible for recovery. We observed an increase in excitatory input correlated with recovery rate of neurons in the peri-injured cortex during the first two weeks of training after brain injury. Furthermore, we expressed DREADD (hM3DGq) in this area, and introduced combination of rehabilitation with DREADD activation in animals that had no recovery. These manipulations induced tendency of recovery of motor function.
These results suggest that activation of neurons in the peri-injured area together with rehabilitation is useful to induce recovery of chronic paralysis.
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