Elucidation of the molecular mechanism of the postsynaptic maturation process by the synaptic organizer Cbln1
| Project/Area Number |
18K06492
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
IBATA KEIJI 聖マリアンナ医科大学, 医学部, 講師 (30462659)
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| Co-Investigator(Kenkyū-buntansha) |
幸田 和久 聖マリアンナ医科大学, 医学部, 教授 (40334388)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | プルキンエ細胞 / シナプス形成 / Cbln1 / 小脳 / デルタ型グルタミン酸受容体 |
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| Outline of Final Research Achievements |
Cbln1, a synapse organizer secreted in an activity-dependent manner, forms a tripartite complex with presynaptic neurexin and postsynaptic GluD2 to form and maintain synapses. In this study, we investigated how Cbln1 exerts its effects after binding to postsynaptic GluD2. We found that Cbln1 induces a change in the localization of GluD2. Our results suggest that GluD2 localization changes play a role in the postsynaptic maturation process.
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| Academic Significance and Societal Importance of the Research Achievements |
近年、シナプスの異常が多くの精神疾患の本体であると考えられてきている。本研究では、平行線維－プルキンエ細胞シナプスにおけるシナプス後部の成熟のメカニズムの一部を明らかにした。本成果とさらなる研究によってシナプスの形成・維持およびその可塑性の分子メカニズムを明らかにすることで、脳機能のメカニズムを理解し、同時に、その病態を解明することにつながると考えている。
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Report
(4 results)
Research Products
(2 results)
