Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Outline of Final Research Achievements |
To test whether organelles involved in secretory pathway change their localizations during synaptic plasticity, live imaging of ER and ERGIC was performed. These organelles accumulated in the vicinity of the stimulated-spine. Microtubules play important roles in the motility of organelles in dendritic shaft. I therefore examined whether the dynamics of microtubules is involved in the synaptic plasticity. Spines are enlarged by the treatment with Nocodazole. In contrast, stimulation-induced change in spine was suppressed by Taxol treatment. These results suggested that the dynamics of microtubules is involved in the synaptic plasticity.
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