| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
In this study, cellular mechanisms underlying high-frequency network oscillation were examined using subcellular recordings from the axon terminal, uncaging of a photoreactive compound, and a numerical simulation approach. Application of 4-aminopyridine, a blocker of voltage-dependent potassium channels, elicited robust burst firings of hippocampal mossy fibers originated from the distal axon, not from the physiological spike initiation site of the proximal axon. The triggering of ectopic burst required propagating action potentials from the soma. The detailed mechanisms for the ectopic oscillation remained to be elucidated.
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