| Project/Area Number |
18K06515
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46030:Function of nervous system-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
Sakurai Katsuyasu 筑波大学, 国際統合睡眠医科学研究機構, 助教 (70507920)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 体温 / 恐怖 / 視床下核 / Trpa1 / 神経回路 / 心拍数 |
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| Outline of Final Research Achievements |
Emotions such as fear can trigger acute changes in body temperature accompanying defensive behaviors to enhance survival in life-threatening conditions. The neural mechanisms of fear-associated thermoregulation remains unknown. In this project, we found that innate fear odor 2-methyl-2-thiazoline (2MT) evokes rapid hypothermia and elevated tail temperature, indicative of vasodilation-mediated heat dissipation, in wild-type mice, but not in mice lacking Trpa1, a chemosensor for 2MT. We identified posterior subthalamic nucleus (PSTh) as a novel thermoregulatory hub through comparative c-fos mapping, opto-/chemo-genetics, and neural circuit/cell type specific neural manipulations. We discovered a novel PBel-PSTh-NTS circuit, whereby 2MT-evoked innate fear signal was transmitted from the external lateral parabrachial subnucleus (PBel) to the nucleus of the solitary tract (NTS) through PSTh to induce innate fear-associated hypothermia and tail vasodilation.
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| Academic Significance and Societal Importance of the Research Achievements |
ヒトを含めた哺乳類のような恒温動物では、体温が一定の温度に保たれている。しかし、恐怖を含めた情動の変化によって、一定に保たれていた体温が急激に変化する。特に、生死に関わるような強烈な恐怖下では、体温の低下が引き起こされることがあるが、その脳内メカニズムは明らかにされていなかった。本研究では、マウスの本能的恐怖刺激モデルを用いて、恐怖刺激に対する急激な体温低下に関与する新規の神経回路を明らかにした。
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