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Neural mechanism for binocular stereopsis --Output pathway of convergent eye movements --

Research Project

Project/Area Number 18K06517
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Sugiuchi Yuriko  東京医科歯科大学, 大学院医歯学総合研究科, 准教授 (30251523)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords輻輳 / 上丘 / 中脳網様体 / 眼球運動
Outline of Final Research Achievements

Neural mechanism of convergent eye movements has not been well analyzed so far. We so far showed the detailed neural circuits for saccadic eye movements from the superior collisulus to ocular motoneurons. In addition, our previous study revealed that the superior colliculus also exerts excitation for convergent eye movements on medial rectus motoneurons, which is mediated by the supraoculomotor area (SOA). The present study revealed that neurons located in the midbrain reticular formation lateral to the SOA are also involved in transmission of such input. The results suggest that neurons in the SOA and the adjacent region in the midbrain reticular formation in the cat may constitute a functional unit in the output pathway of convergent eye movements, and that these neurons are likely to be involved in disjunctive eye movements.

Academic Significance and Societal Importance of the Research Achievements

本研究により、輻輳性眼球運動が、従来共同性眼球運動であるサッケードの中枢とされてきた上丘内の最頭側部の輻輳関連領域から、SOAから中脳網様体にかけての領域を介して内直筋に出力されることが明らかとなった。斜め遠方から目前の点に視線が移動する(disjunctive saccade)場合の、速い共同性眼球運動(サッケード)と緩徐な輻輳運動が同時に起こる(saccade-vergence interaction)ための神経機構は未解明であるが、本研究で明らかとなった、SOAから中脳網様体にかけての領域が両者の相互作用に関与している可能性があり、臨床例における局所診断のヒントになりうると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (10 results)

All 2020 2019 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] 急性期めまいの診療フローチャート2019

    • Author(s)
      宇佐美 真一, 室伏 利久, 北原 糺, 内藤 泰, 牛尾 宗貴, 城倉 健, 伏木 宏彰, 中村 正, 関根 和教, 宇野 敦彦, 杉内 友理子
    • Journal Title

      Equilibrium Research

      Volume: 78 Issue: 6 Pages: 607-610

    • DOI

      10.3757/jser.78.607

    • NAID

      130007795206

    • ISSN
      0385-5716, 1882-577X
    • Year and Date
      2019-12-31
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brainstem Neural Circuits for Fixation and Generation of Saccadic Eye Movements.2019

    • Author(s)
      Shinoda Y., Takahashi M., and Sugiuchi Y.
    • Journal Title

      Progress in Brain Research

      Volume: 249 Pages: 95-104

    • DOI

      10.1016/bs.pbr.2019.04.007

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 前庭脊髄系の解剖と生理2020

    • Author(s)
      杉内友理子
    • Organizer
      第79回日本めまい平衡医学会総会学術講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 頸部屈筋及び伸筋運動ニューロンへの三半規管入力の比較2019

    • Author(s)
      杉内友理子, 八木淳一、篠田義一
    • Organizer
      第78回日本めまい平衡医学会総会学術講演会
    • Related Report
      2019 Research-status Report
  • [Presentation] サッケード眼球運動制御に関わる小脳虫部後部と室頂核の入-出力機構 Input-Output organization of the posterior vermis and fastigial nucleus for control of saccadic eye movements2018

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第41回神経科学大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Neural Substrates of Functional Synergies -- Structural Basis for Muscle Synergies in the Eye-head Motor System―2018

    • Author(s)
      Yuriko Sugiuchi
    • Organizer
      The 2nd International Symposium on Embodied-Brain System Scinece (Embos2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 頚部腹側筋への左右6個の半規管からの入力様式とその中枢経路2018

    • Author(s)
      杉内友理子、八木淳一、篠田義一
    • Organizer
      第77回日本めまい平衡医学会総会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 垂直サッケードの中枢神経回路2018

    • Author(s)
      高橋真有、杉内友理子、篠田義一
    • Organizer
      第77回日本めまい平衡医学会総会学術講演会
    • Related Report
      2018 Research-status Report
  • [Presentation] 頚部運動系における筋シナジー形成の神経基盤2018

    • Author(s)
      杉内友理子
    • Organizer
      第7回身体性システム領域全体会議
    • Related Report
      2018 Research-status Report
  • [Book] 標準生理学2019

    • Author(s)
      河合泰明、黒澤美枝子、鯉淵典之、伊佐正、杉内友理子 他
    • Total Pages
      1172
    • Publisher
      医学書院
    • ISBN
      9784260034296
    • Related Report
      2019 Research-status Report 2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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