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Development of regioselective sp3 C-H functionalization catalyst with substrate recognition site

Research Project

Project/Area Number 18K06545
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Research InstitutionThe University of Tokyo

Principal Investigator

Oisaki Kounosuke  東京大学, 大学院薬学系研究科(薬学部), 講師 (00583999)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsC-H活性化 / 有機ラジカル / フォトレドックス触媒 / 水素原子移動触媒 / 結合弱化触媒 / 有機合成化学 / 化学選択性 / 均一系触媒
Outline of Final Research Achievements

We have been working on the development of catalysts that enable catalytic control of site-selectivity, which is an unsolved problem in catalytic C(sp3)-H transformation.
(1) By designing HAT catalysts with alcohol recognition moiety, we attempted to achieve site-selective C(sp3)-H transformations through a pseudo-intramolecular transition state. However, this approach was abandoned in the face of various problems.
(2) We conducted DFT-guided screening of bond-weakening catalysts that could lower the bond dissociation energy (BDE) by recognizing alcohol moiety, and found silicate or borate species to be candidates. Based on this finding, we developed a cooperative catalytic system promoting alcohol alpha-C-H alkylations using Martin spirosilane and electron-deficient boric acid as the embodiment of bond-weakening catalyst.

Academic Significance and Societal Importance of the Research Achievements

最終生成物に頻度高く含まれる官能基(ヒドロキシル基やカルボニル基など)を足がかりとし、各々のC-H結合を区別したうえで位置選択的な変換可能な触媒を開発できれば、物質機能を担保したうえでの構造展開を可能とするLate-Stage誘導体化法の拡充や、複雑化合物の合成短工程化にも寄与し、機能性物質創製プロセスを加速させるような方法論となることが期待される。本研究にて開発に成功した結合弱化触媒系は、現在世界中の研究者が取り組んでいるC(sp3)-H変換触媒開発とその位置選択性制御という重要課題に対し、解決をもたらしうる全く新たな角度からの触媒設計指針を提供する。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (65 results)

All 2021 2020 2019 2018 Other

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 3 results) Presentation (48 results) (of which Int'l Joint Research: 15 results,  Invited: 9 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] A Bond-Weakening Borinate Catalyst that Improves the Scope of the Photoredox α-C?H Alkylation of Alcohols2020

    • Author(s)
      Oisaki Kounosuke、Kanai Motomu、Sakai Kentaro
    • Journal Title

      Synthesis

      Volume: 52 Issue: 15 Pages: 2171-2189

    • DOI

      10.1055/s-0040-1707114

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Induction of ADCC by a folic acid?mAb conjugate prepared by tryptophan-selective reaction toward folate-receptor-positive cancer cells2020

    • Author(s)
      Tagawa Hiroshi、Maruyama Katsuya、Sasaki Koichi、Konoue Natsuki、Kishimura Akihiro、Kanai Motomu、Mori Takeshi、Oisaki Kounosuke、Katayama Yoshiki
    • Journal Title

      RSC Advances

      Volume: 10 Issue: 28 Pages: 16727-16731

    • DOI

      10.1039/d0ra03291c

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Tryptophan?Folate Conjugates2020

    • Author(s)
      Maruyama Katsuya、Malawska Katarzyna Joanna、Konoue Natsuki、Oisaki Kounosuke、Kanai Motomu
    • Journal Title

      Synlett

      Volume: 31 Issue: 08 Pages: 784-787

    • DOI

      10.1055/s-0039-1691735

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Bond‐Weakening Spirosilane Catalyst for Photoredox α‐C-H Alkylation of Alcohols2019

    • Author(s)
      Sakai Kentaro、Oisaki Kounosuke、Kanai Motomu
    • Journal Title

      Advanced Synthesis & Catalysis

      Volume: 362 Issue: 2 Pages: 337-343

    • DOI

      10.1002/adsc.201901253

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Catalytic Regio- and Enantioselective Proton Migration from Skipped Enynes to Allenes2019

    • Author(s)
      Wei Xiao-Feng、Wakaki Takayuki、Itoh Taisuke、Li Hong-Liang、Yoshimura Takayoshi、Miyazaki Aya、Oisaki Kounosuke、Hatanaka Miho、Shimizu Yohei、Kanai Motomu
    • Journal Title

      Chem

      Volume: 5 Issue: 3 Pages: 585-599

    • DOI

      10.1016/j.chempr.2018.11.022

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Development of Highly Chemoselective Oxidative Transformations by Designing Organoradicals2018

    • Author(s)
      Oisaki Kounosuke
    • Journal Title

      Chemical and Pharmaceutical Bulletin

      Volume: 66 Issue: 10 Pages: 907-919

    • DOI

      10.1248/cpb.c18-00501

    • NAID

      130007491386

    • ISSN
      0009-2363, 1347-5223
    • Year and Date
      2018-10-01
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organophotoredox/Copper Hybrid Catalysis for Regioselective Allylic Aminodecarboxylation of β,γ-Unsaturated Carboxylic Acids2018

    • Author(s)
      Oisaki Kounosuke、Kanai Motomu、Manick Anne-Doriane、Tanaka Hirotaka
    • Journal Title

      Synthesis

      Volume: 50 Issue: 15 Pages: 2936-2947

    • DOI

      10.1055/s-0036-1591983

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 均質な抗体-薬物複合体とその製造法2018

    • Author(s)
      生長幸之助
    • Journal Title

      化学と教育

      Volume: 66 Pages: 236-237

    • NAID

      130007641135

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 有機ラジカルを用いたタンパク質変換法の開発-実験的観察とコラボが紡ぎ出す開発ストーリー2018

    • Author(s)
      生長幸之助
    • Journal Title

      化学と工業

      Volume: 71 Pages: 605-606

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] C(sp3)-H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis2018

    • Author(s)
      Wakaki Takayuki、Sakai Kentaro、Enomoto Takafumi、Kondo Mio、Masaoka Shigeyuki、Oisaki Kounosuke、Kanai Motomu
    • Journal Title

      Chemistry - A European Journal

      Volume: 24 Issue: 32 Pages: 8051-8055

    • DOI

      10.1002/chem.201801746

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A catalytic one-step synthesis of peptide thioacids: the synthesis of leuprorelin via iterative peptide fragment coupling reactions2018

    • Author(s)
      Matsumoto Takuya、Sasamoto Koki、Hirano Ryo、Oisaki Kounosuke、Kanai Motomu
    • Journal Title

      Chemical Communications

      Volume: 54 Issue: 86 Pages: 12222-12225

    • DOI

      10.1039/c8cc07935h

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Convergent and Functional-Group-Tolerant Synthesis of B-Organo BODIPYs2018

    • Author(s)
      Sawazaki Taka、Shimizu Yusuke、Oisaki Kounosuke、Sohma Youhei、Kanai Motomu
    • Journal Title

      Organic Letters

      Volume: 20 Issue: 24 Pages: 7767-7770

    • DOI

      10.1021/acs.orglett.8b03138

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] 9-Azabicyclo[3.3.1]nonan-3-one N-oxyl (keto-ABNO)2018

    • Author(s)
      Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai
    • Journal Title

      Electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS)

      Volume: なし

    • Related Report
      2018 Research-status Report
  • [Presentation] タンパク質の化学アップグレード法2021

    • Author(s)
      生長 幸之助
    • Organizer
      日本薬学会北陸支部特別講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ホウ素型新規結合弱化触媒を用いたアルコールα位C(sp3)-Hアルキル化2021

    • Author(s)
      坂井健太郎、生長幸之助、金井求
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 抗体修飾を指向した電気化学的トリプトファン修飾反応の最適化2021

    • Author(s)
      高上夏希、外山瑛章、Malawska Katarzyna、生長幸之助、金井求
    • Organizer
      日本薬学会 第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 抗体医薬-葉酸コンジュゲートのトリプトファン選択的修飾による作製と葉酸受容体陽性のがん細胞に対するADCCの誘導2020

    • Author(s)
      谷戸 謙太、田川 寛、丸山 勝矢、佐々木 光一、高上 夏希、岸村 顕広、金井 求、森 健、生長 幸之助、片山 佳樹
    • Organizer
      第14回バイオ関連化学シンポジウム2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] ADCC Induced by Folic Acid-mAb Conjugate Produced by Tryptophan-selective Bioconjugation2020

    • Author(s)
      丸山勝矢、田川寛、佐々木光一、高上夏希、金井求、森健、生長幸之助、片山佳樹
    • Organizer
      第20回 東京大学生命科学シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] ペプチドチオ酸を用いたペプチド合成法の開発2020

    • Author(s)
      笹本 晃生, 巽 俊文, 平野遼, 松本拓也, 生長 幸之助, 金井求
    • Organizer
      日本薬学会第140年会(京都)
    • Related Report
      2019 Research-status Report
  • [Presentation] 新規結合弱化触媒を用いた可視光駆動型アルコールα位C-Hアルキル化2020

    • Author(s)
      坂井健太郎, 生長 幸之助, 金井 求
    • Organizer
      日本薬学会第140年会(京都)
    • Related Report
      2019 Research-status Report
  • [Presentation] 有機ラジカルの設計に基づくC(sp3)-H変換反応の開発2019

    • Author(s)
      生長 幸之助
    • Organizer
      ファインケミカルズ合成触媒研究会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Electrochemical Tryptophan-Selective Bioconjugation2019

    • Author(s)
      Eisho Toyama, Katsuya Maruyama, Tomoya Sugai, Mio Kondo, Shigeyuki Masaoka, Tsuyoshi Saitoh, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The 1st International Symposium on Hybrid Catalysis for Enabling Molecular Synthesis on Demand
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Tryptophan-Targeted Homogeneous Antibody-Drug Conjugates2019

    • Author(s)
      Katsuya Maruyama, Takashi Ishiyama, Atsushi Kawamura, Kuniko Saiki, Yuki Kobayashi, Yohei Seki, Keita Iguchi, Masaru Mitsuda, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The 1st International Symposium on Hybrid Catalysis for Enabling Molecular Synthesis on Demand
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] MSn Analyses for Tryptophan-Conjugated ADC Mimic by Miniature MALDI Digital Ion Trap Mass Spectrometer (MALDI-DIT-MS)2019

    • Author(s)
      Hideharu Shichi, Shuichi Nakaya, Katsuya Maruyama, Kosuke Hosoi, Takashi Nishikaze, Koichi Kojima, Kei Kodera, Sadanori Sekiya, Shinichi Iwamoto, Kounosuke Oisaki, Motomu Kanai, Koichi Tanaka
    • Organizer
      The 67th ASMS Conference on Mass Spectrometry and Allied Topics
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 有機ラジカルを用いるタンパク質修飾法の開発と応用2019

    • Author(s)
      生長 幸之助
    • Organizer
      2019年度前期(春季)有機合成化学講習会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 電気化学的手法を用いたトリプトファン選択的タンパク質修飾反応の開発2019

    • Author(s)
      外山瑛章, 丸山勝矢, 生長幸之助, 金井求
    • Organizer
      第8回JACI/GSCシンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] 電気化学的なトリプトファン選択的タンパク質修飾反応2019

    • Author(s)
      生長幸之助, 外山瑛章, 丸山勝矢, 須貝智也, 近藤美欧, 正岡重行, 斉藤 毅, 金井 求
    • Organizer
      第43回有機電子移動化学討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] トリプトファン連結型均質抗体―薬物複合体の開発2019

    • Author(s)
      丸山勝矢, 石山隆史, 河村篤, 斎木邦子, 小林由紀, 関陽平, 井口恵太, 満田勝, 生長幸之助, 金井求
    • Organizer
      第54回天然物化学談話会
    • Related Report
      2019 Research-status Report
  • [Presentation] 有機ラジカルを用いるタンパク質修飾法の開発と応用2019

    • Author(s)
      生長 幸之助
    • Organizer
      生体機能関連化学若手の会・第31回サマースクール
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Electrochemical Tryptophan-Selective Bioconjugation2019

    • Author(s)
      Kounosuke Oisaki, Eisho Toyama, Katsuya Maruyama, Tomoya Sugai, Mio Kondo, Shigeyuki Masaoka, Tsuyoshi Saitoh, Motomu Kanai
    • Organizer
      European Federation for Medicinal Chemistry International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’19)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 有機ラジカルを用いるタンパク質修飾法の開発と応用2019

    • Author(s)
      生長 幸之助
    • Organizer
      第2回理研ケミカルバイオロジー合宿Chemical Probe
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 電気化学的手法を用いたトリプトファン選択的タンパク質修飾反応の開発2019

    • Author(s)
      外山瑛章, 丸山勝矢, 須貝智也, 近藤美欧, 正岡重行, 斉藤毅, 生長 幸之助, 金井求
    • Organizer
      新学術領域「分子夾雑の生命化学」第2回 関東地区シンポジウム
    • Related Report
      2019 Research-status Report
  • [Presentation] ELECTROCHEMICAL TRYPTOPHAN-SELECTIVE BIOCONJUGATION OF PROTEINS2019

    • Author(s)
      生長 幸之助, 外山瑛章, 丸山勝矢, 須貝智也, 近藤美欧, 正岡重行, 斉藤毅, 金井求
    • Organizer
      第56回ペプチド討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] Electrochemical Tryptophan-Selective Bioconjugation2019

    • Author(s)
      Kounosuke Oisaki, Eisho Toyama, Katsuya Maruyama, Tomoya Sugai, Mio Kondo, Shigeyuki Masaoka, Tsuyoshi Saitoh, Motomu Kanai
    • Organizer
      19th Tateshina Conference on Organic Chemistry
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] A Bond-Weakening Borinate Complex for Improved Scope of Photoredox α-C-H Alkylation of Alcohols2019

    • Author(s)
      Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Identification of Bond-Weakening Spirosilane Catalyst for Photoredox α-C-H Alkylation of Alcohols2019

    • Author(s)
      Kentaro Sakai, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      4th International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ホウ素-フォトレドックス-HATハイブリッド触媒系によるアルコールα-C-H官能基化反応2019

    • Author(s)
      坂井健太郎、生長幸之助、金井求
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] C(sp3)-H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis2019

    • Author(s)
      WAKAKI, Takayuki; SAKAI, Kentaro; ENOMOTO, Takafumi; KONDO, Mio; MASAOKA, Shigeyuki; OISAKI, Kounosuke; KANAI, Motomu
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] トリプトファン連結型均質抗体-薬物複合体の開発2019

    • Author(s)
      丸山勝矢、石山隆史、河村篤、斎木邦子、小林由紀、関陽平、井口恵太、満田勝、生長幸之助、金井求
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Catalytic one-step synthesis of peptide thioacids and application to amino acid linkage2019

    • Author(s)
      OISAKI, Kounosuke; MATSUMOTO, Takuya; SASAMOTO, Koki; HIRANO, Ryo; KANAI, Motomu
    • Organizer
      日本化学会第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 化学系プレプリント(ChemRxiv)の活用法を考える2019

    • Author(s)
      生長幸之助
    • Organizer
      日本化学会 第99春季年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] B-オルガノBODIPYの官能基許容性に優れた収束的合成法の開発2019

    • Author(s)
      澤崎鷹、清水裕介、生長幸之助、相馬洋平、金井求
    • Organizer
      日本化学会 第99春季年会
    • Related Report
      2018 Research-status Report
  • [Presentation] 有機ラジカルを用いる化学選択的タンパク質変換反応の開発と応用2019

    • Author(s)
      生長幸之助
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 高機能性色素の開発を指向したBオルガノBODIPYの収束的合成法の確立2019

    • Author(s)
      澤崎鷹、清水裕介、生長幸之助、相馬洋平、金井求
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Concisely Produced Homogeneous Antibody-Drug Conjugates by A Tryptophan-Selective Protein Bioconjugation2018

    • Author(s)
      Kounosuke Oisaki, Takashi Ishiyama, Kuniko Saiki, Yohei Seki, Keita Iguchi, Masaru Mitsuda, Motomu Kanai
    • Organizer
      14th Annual PEGS Boston
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 有機ラジカルを用いた化学選択的タンパク質変換法の開発2018

    • Author(s)
      生長 幸之助
    • Organizer
      第6回慶應有機化学若手シンポジウム
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 可視光レドックス/リン酸HATハイブリッド触媒系によるC(sp3)-Hシアノ化反応の開発2018

    • Author(s)
      若木 貴行、坂井 健太郎、榎本 孝文,近藤 美欧,正岡 重行,生長 幸之助,金井 求
    • Organizer
      第16回次世代を担う有機化学シンポジウム
    • Related Report
      2018 Research-status Report
  • [Presentation] 触媒的ペプチドチオ酸合成法の開発と連続的ペプチドカップリングへの応用2018

    • Author(s)
      生長幸之助、松本拓也、笹本晃生、平野遼、金井求
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] トリプトファン結合型抗体―薬物複合体の開発2018

    • Author(s)
      河村篤、石山隆史、斎木邦子、丸山勝矢、関陽平、井口恵太、満田勝、生長幸之助、金井求
    • Organizer
      日本ケミカルバイオロジー学会第13回年会
    • Related Report
      2018 Research-status Report
  • [Presentation] ペプチドチオ酸の触媒的一工程合成法とその応用2018

    • Author(s)
      笹本晃生、松本拓也、平野遼、生長 幸之助,金井 求
    • Organizer
      第53回天然物化学談話会
    • Related Report
      2018 Research-status Report
  • [Presentation] 可視光レドックス/リン酸HATハイブリッド触媒系によるC(sp3)-Hシアノ化の開発2018

    • Author(s)
      生長 幸之助
    • Organizer
      第2回触発型有機化学研究会(AIKOC-2)
    • Related Report
      2018 Research-status Report
  • [Presentation] C(sp3)-H Functionalizations Promoted by Structurally Novel Hydrogen Atom Transfer Catalyst2018

    • Author(s)
      Kounosuke Oisaki
    • Organizer
      3rd International Symposium on Precisely Designed Catalysts with Customized Scaffolding
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] C(sp3)-H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis2018

    • Author(s)
      Kounosuke Oisaki, Takayuki Wakaki, Kentaro Sakai, Takafumi Enomoto, Mio Kondo, Shigeyuki Masaoka, Motomu Kanai
    • Organizer
      The 4th International Symposium on C-H Activation (ISCHA-4)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] 可視光レドックス/リン酸HATハイブリッド触媒系によるC(sp3)-Hシアノ化の開発2018

    • Author(s)
      坂井健太郎、若木貴行、榎本孝文、近藤美欧、正岡重行、生長幸之助、金井求
    • Organizer
      第35回有機合成化学セミナー
    • Related Report
      2018 Research-status Report
  • [Presentation] C(sp3)-H Cyanation Promoted by Visible-Light Photoredox/Phosphate Hybrid Catalysis2018

    • Author(s)
      Takayuki Wakaki, Kentaro Sakai, Takafumi Enomoto, Mio Kondo, Shigeyuki Masaoka, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      Frontiers in Chemistry, Armenia (ArmChemFront2018)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Chemoselective Transformations by Radical-Conjugated Redox Catalysis: From Functional Small Molecules to Biomacromolecules2018

    • Author(s)
      Kounosuke Oisaki
    • Organizer
      第8回CSJ化学フェスタ
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Tryptophan-Targeted Homogeneous Antibody-Drug Conjugates2018

    • Author(s)
      Katsuya Maruyama, Takashi Ishiyama, Atsushi Kawamura, Kuniko Saiki, Yuki Kobayashi, Yohei Seki, Keita Iguchi, Masaru Mitsuda, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The 9th International Forum on Chemistry of Functional Organic Chemicals (IFOC-9)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Catalytic One-step Synthesis of Peptide Thioacids2018

    • Author(s)
      Koki Sasamoto, Takuya Matsumoto, Ryo Hirano, Kounosuke Oisaki, Motomu Kanai
    • Organizer
      The 9th International Forum on Chemistry of Functional Organic Chemicals (IFOC-9)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Concisely Produced Homogeneous Antibody-Drug Conjugates by A Tryptophan-Selective Protein Bioconjugation2018

    • Author(s)
      Kounosuke Oisaki, Takashi Ishiyama, Kuniko Saiki, Yohei Seki, Keita Iguchi, Masaru Mitsuda, Motomu Kanai
    • Organizer
      9th World ADC San Diego 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Homogeneous Antibody-Drug Conjugates (ADCs) by a Tryptophan-Selective Protein Bioconjugation2018

    • Author(s)
      Kounosuke Oisaki, Takashi Ishiyama, Atsushi Kawamura, Kuniko Saiki, Yuki Kobayashi, Katsuya Maruyama, Yohei Seki, Keita Iguchi, Masaru Mitsuda, Motomu Kanai
    • Organizer
      10th International Peptide Symposium
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] C(sp3)-H官能基化反応を実現するスルホンアミド型新規HAT触媒開発2018

    • Author(s)
      坂井健太郎、田中博隆、河村篤、生長幸之助、金井求
    • Organizer
      第11回有機触媒シンポジウム
    • Related Report
      2018 Research-status Report
  • [Remarks] 金井研究室発表論文リスト

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/index.html

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
  • [Remarks] 金井研究室論文リスト

    • URL

      http://www.f.u-tokyo.ac.jp/~kanai/publication/index.html

    • Related Report
      2018 Research-status Report
  • [Patent(Industrial Property Rights)] ペプチド合成法2020

    • Inventor(s)
      金井求、生長幸之助、笹本晃生、平野遼、松本拓也
    • Industrial Property Rights Holder
      株式会社東京大学TLO
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-024974
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report
  • [Patent(Industrial Property Rights)] アミノ酸残基選択的な不可逆/可逆生体分子修飾法2020

    • Inventor(s)
      金井求、生長幸之助、丸山勝矢、石山隆史、関陽平
    • Industrial Property Rights Holder
      株式会社東京大学TLO
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Research-status Report
    • Overseas

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Published: 2018-04-23   Modified: 2022-01-27  

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