| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Photoremovable protective groups, whose covalent bond could be cleaved by the irradiation of light yielding spatio- and temporally controlled release of bioactive compound or fluorophore, have been utilized in biological study. In this research, such groups that could function under specific environments like a specific range of pH and the presence of hydrogen peroxide have been developed. Such chemically gated photoremovable protective groups could potentially be utilized in photo-releasing a drug selectively around cancer tissue. In addition, those compounds could be utilized in the development of novel type of photofunctional molecules, fluorescent integrator.
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