| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Accumulation of neutral lipids (cholesteryl ester (CE) and triglyceride (TG) as lipid droplet triggers inflammation and fibrosis, and finally progresses NASH. Therefor it is very important to discovery drugs for the treatment of NAFLD/NASH. In this study, 1) Screening for microbial lipid droplet accumulation inhibitors or lipid degradation promoter, 2) In vivo experiments of microbial lipid metabolism inhibitors using mouse models and 3) Search for the mode of action of microbial lipid metabolism inhibitors (from 1)) were investigated.
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