| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The purpose of this research has been established the development of the chiral ligand containing indazole ring system. The ligand, which has oxygen atom and nitrogen atom in indazole ring as ligation atoms, was synthesized with some racemization. But it did not work well for chiral induction during the allylation reactions. Next, we successfully synthesized the ligand, which has phosphorus atom and nitrogen atom in indazole ring as ligation atoms. However, it was impossible to keep high level optical purity during synthesizing the ligands. Therefore, we designed new type compounds having the asymmetric center at beta position of the nitrogen atom in the indazole ring and it was successfully synthesized by short steps. The confirmation of this ligand and the optimization of the structure is underway.
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