| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Aβ that is produced in the β-secretase pathway is thought to be a causative agent in the development of AD. Recently, a third secretase pathway has been reported as a factor in AD pathogenesis. In this research project, we will develop β-secretase inhibitors and design and synthesize η-secretase inhibitors based on the η-secretase hypothesis. We have already developed potent BACE1 inhibitors. These compounds are now available as research reagents from FUJIFILM Wako Pure Chemical Industries, Ltd. In addition, we have found some compounds with weak inhibitory activity against η-secretase in the evaluation of inhibitory activity using η-secretase.
|
