| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we aimed to develop novel environmentally benign catalytic reactions for the direct synthesis of a wide range of N-unprotected unnatural amino acids based on a new strategy using N-unprotected substrates. As a result, we succeeded in developing various catalytic nucleophilic addition reactions to N-unprotected ketimines and established a method for the direct synthesis of a wide range of N-unprotected unnatural amino acids. In addition, we have developed a new direct catalytic synthesis method for N-unprotected ketimines, which can be applied to large-scale synthesis and compatible with various functional groups.
|
