| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The palladium-catalyzed selective oxidation of the heterocycle-containing alcohols was developed by using an N-heterocyclic carbene (NHC) ligand. In this research, the optimization of reaction conditions was conducted aimed at achieving the selective transformation of alcohols especially with reactive N-heterocycles. Our original catalyst system and the use of stable reoxidants allowed the alcohol oxidation for substrates bearing aromatic and aliphatic N-heterocycles with efficient selectivity. In this method, the challenging 1,2-aminoalcohols were also tolerated, and the high level of selectivity and the broad scope of substrates were realized.
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