| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
To apply the new administration system to the peritoneal organ surface for chemotherapy, we have tried to produce a two-layer sheet including anticancer drug doxorubicin and formulation additives, and examined the drug disposition and anticancer effect after application to the subcutaneous tumor model mouse. We could observe selective drug accumulation in the tumor, significant anticancer effect and less side-effect. In addition, we have examined the drug absorption and distribution of a drug after application to the liver surface in detail. We could analyze the spatial distribution of doxorubicin by utilizing new transparency agent.
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