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Investigation of PATM syndrome based on human skin gas analysis

Research Project

Project/Area Number 18K06607
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related
Research InstitutionTokai University

Principal Investigator

Sekine Yoshika  東海大学, 理学部, 教授 (50328100)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords皮膚ガス / PATM / 化学物質 / 体臭 / ガスクロマトグラフィー / 室内環境 / 分析 / 皮膚 / 拡散濃度 / 嗅覚閾値 / skin gas / VOCs / dermal emission / indoor environment
Outline of Final Research Achievements

Although trace gases emanating from human skin surface often cause body odor, little has been known for their adverse effects on human health. However, there exist some people who claim his/her body odor provokes allergy like reactions of people in their near vicinity. This symptom or phenomenon is called "People Allergic To Me (PATM) " which has been almost unrecognized and unpublished in scientific and medical journals. This study aimed to characterize the human skin gas composition of people who claimed PATM. Dermal emission fluxes of 75 kinds of human skin gas were determined at the forearm of recruited subjects employing a passive flux sampler coupled with gas chromatography-mass spectrometry. The results showed the human skin pattern of subjects who claimed PATM were significantly different with that of healthy volunteers with a possible release of chemicals which causes unpleasant odor and hazardous effect by exposure.

Academic Significance and Societal Importance of the Research Achievements

本研究により、PATMを主訴する人たちの皮膚ガス組成の特徴が明らかとなり、PATMと呼ばれる現象・症状は、物理・化学的に成立し得ることがわかった。本研究の成果は、これまで全く手つかずであったPATM症候群が科学的・医学的な研究対象になり得ることを示すものであり、PATMによって社会生活に支障をきたしている人たちの問題解決の糸口になることが期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (19 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 8 results) Book (1 results)

  • [Int'l Joint Research] PATM patient(フランス)

    • Related Report
      2019 Research-status Report
  • [Journal Article] ヒト皮膚ガスが室内臭気に及ぼす影響2020

    • Author(s)
      福嶋和真,関根嘉香
    • Journal Title

      クリーンテクノロジー

      Volume: 30 Pages: 35-38

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Measurement of toluene emanating from the surface of human skin in relation to toluene inhalation2019

    • Author(s)
      Sekine,Y., Nikaido,N., Sato,S., Todaka,M., Oikawa,D.
    • Journal Title

      Journal of Skin and Stem Cell

      Volume: 6 Issue: 1

    • DOI

      10.5812/jssc.99392

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ヒト皮膚から放散される微量生体ガスの測定とその利用2019

    • Author(s)
      関根嘉香
    • Journal Title

      環境技術

      Volume: 48 Pages: 205-209

    • NAID

      40021976343

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] An exploratory study on "people allergic to me" syndrome based on measurement of trace gases released from skin surface and microbial species in nasal cavity of a patient2018

    • Author(s)
      川上裕司, 関根嘉香,木村桂大,戸高惣史,小田尚幸
    • Journal Title

      Indoor Environment

      Volume: 21 Issue: 1 Pages: 19-30

    • DOI

      10.7879/siej.21.19

    • NAID

      130006602840

    • ISSN
      1882-0395, 2186-4322
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] いつでもどこでも 「体のにおい」で健康診断2021

    • Author(s)
      関根嘉香
    • Organizer
      静岡県保険医協会西部支部総会記念講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Human skin gas and indoor environment2020

    • Author(s)
      Sekine,Y.
    • Organizer
      Indoor Air 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 皮膚ガスを生体情報として活用する2020

    • Author(s)
      関根嘉香
    • Organizer
      サイレントボイスセンシング国際シンポジウム2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト皮膚ガス測定に基づくPATM(People Allergic To Me)症候群に関する研究2020

    • Author(s)
      関根嘉香,戸髙惣史,笈川大介
    • Organizer
      第33回におい・かおり環境学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト皮膚表面から放散される微量生体ガスの室内拡散濃度の推定2019

    • Author(s)
      福嶋和真,関根嘉香,戸高惣史,内山汐里,笈川大介
    • Organizer
      2019年室内環境学会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] PATM(People Allergic To Me)症候群の実態解明に関する研究2019

    • Author(s)
      戸高惣史,二階堂直樹,関根嘉香
    • Organizer
      第28回日本臨床環境医学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] ヒト皮膚から放散する微量生体ガスの測定とその利用2019

    • Author(s)
      関根嘉香
    • Organizer
      日本分析化学会第68年会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] PATM 患者の皮膚から放散される微量生体ガスの室内拡散濃度の推定2018

    • Author(s)
      戸髙惣史,佐藤祥大,木村桂大,川上裕司,小田尚幸,関根嘉香
    • Organizer
      平成30年室内環境学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 室内環境の見える化~皮膚ガス測定の観点から2018

    • Author(s)
      関根嘉香
    • Organizer
      平成30年室内環境学会学術大会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Wellness monitoring via human skin gas in indoor environment2018

    • Author(s)
      Yoshika Sekine
    • Organizer
      International Symposium, 15th Annual Meeting of Korean Society of Indoor Environment
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 生体ガスを利用した室内化学物質曝露評価の今後の展開2018

    • Author(s)
      関根嘉香
    • Organizer
      環境科学会2018年会シンポジウム―2「室内環境における化学物質管理の現状と関連法規制の動向
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] ヒト皮膚ガス分析に基づくPATM(People Allergic To Me)症候群の検討2018

    • Author(s)
      関根嘉香,戸高惣史,木村桂大,川上裕司,梅澤和夫,浅井さとみ
    • Organizer
      第27回日本臨床環境医学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 皮膚ガス測定による疾病予防の可能性2018

    • Author(s)
      関根嘉香
    • Organizer
      第91回日本産業衛生学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Book] 匂いのセンシング技術2020

    • Author(s)
      中本高道
    • Total Pages
      289
    • Publisher
      シーエムシー出版
    • ISBN
      9784781315157
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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