Possible role of AKT in chromosome seggregation, instability and aneuploidy
| Project/Area Number |
18K06632
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Tokyo University of Science (2020)
Yokohama College of Pharmacy (2019)
Keio University (2018) |
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Principal Investigator |
Noguchi Kohji 東京理科大学, 薬学部薬学科, 教授 (80291136)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | AKT / 細胞分裂 / キナーゼ / リン酸化 / がん / 染色体分配 / 異数体性 / 染色体 |
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| Outline of Final Research Achievements |
The purpose of this study was to clarify the role of cancer-related kinase AKT in chromosome instability and its regulatory mechanism. We found that in metaphase, AKT1 and AKT3 were localized to partially overlap Aurora kinase in the central spindle, and that treatment with AKT inhibitors multipolarized the tubulin spindle that acts on chromosome division. Furthermore, we found KIF23 as a new target molecule candidate for AKT. Phosphorylation of KIF23 by AKT was found to be involved in the localization of KIF23 to the midbody during cell division, demonstrating that AKT3 functions in the cell division mechanism.
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| Academic Significance and Societal Importance of the Research Achievements |
細胞分裂不全などで生じた核の多倍数化細胞や異数体性の細胞は最終的に細胞死を起こすが、なぜ異数体性がん細胞が無限増殖できるのかという点については未解明である。本研究で、異数体性がん細胞における染色体不安定性の動的制御機構においてがん関連キナーゼのAKTが関与するメカニズムが解明できれば、新しいがん治療戦略の開発にも貢献できると期待される。
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Cytotoxicity comparison of 35 developmental neurotoxicants in human induced pluripotent stem cells (iPSC), iPSC-derived neural progenitor cells, and transformed cell lines.2020
Author(s)
Kamata S,Hashiyama R,Hana-Ika H,Ohkubo I,Saito R,Honda A,Anan Y,Akahoshi N,Noguchi K,Kanda Y,Ishii I
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Journal Title
Toxicology In vitro
Volume: 69
Pages: 104999-104999
DOI
Related Report
Peer Reviewed
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[Book] 図解 腫瘍薬学2020
Author(s)
野口耕司 他
Total Pages
677
Publisher
南山堂
ISBN
9784525721619
Related Report
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