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The mechanism of broadly reactive anti-influenza virus antibody responses

Research Project

Project/Area Number 18K06647
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Miyauchi Kosuke  国立研究開発法人理化学研究所, 生命医科学研究センター, 副チームリーダー (50619856)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsウイルス中和抗体 / インフルエンザウイルス / 濾胞性ヘルパーT細胞 / 抗インフルエンザウイルス抗体 / 広域中和抗体 / 抗ウイルス抗体 / ワクチン / 中和抗体 / ヘルパーT細胞
Outline of Final Research Achievements

Here, we investigated virus-specific antibody responses against the influenza virus infection to elucidate the production mechanism of broadly neutralizing antibodies, which will give us new insight for the development of a universal vaccine. To analyze the immune response induced in the lung by influenza virus infection, we performed transcriptome analysis of lung cells isolated from influenza virus infected mice. In addition, to analyze the difference in virus antigen-specific B cell responses between the infection with live viruses and the vaccination with inactivated viruses, we isolated virus-specific B cells and analyzed their IgG genes. Based on results of these experiments, we revealed that the activation of virus-specific follicular helper T cells in the lung draining lymph nodes induced by infection and the exposure of viral antigens to lung immune system play important roles in the induction of broadly neutralizing antibody responses.

Academic Significance and Societal Importance of the Research Achievements

本研究においてインフルエンザウイルス感染時における広域中和抗体の産生メカニズムの一端が解明できたことで、新興インフルエンザウイルス感染症に対抗するためのユニバーサルワクチンの開発に向けて有用な基礎データを提供できた。これによって、安全性の高い不活化ワクチンを使用しながら、濾胞性ヘルパーT細胞を活性化することで、広域中和抗体を誘導するワクチン投与法の検討を進める方針が確認出来たことは、今後の抗ウイルスワクチン研究において大きな意義をもつと考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2020

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Breadth of Antibody Responses during Influenza Virus Infection and Vaccination2020

    • Author(s)
      Kubo Masato、Miyauchi Kosuke
    • Journal Title

      Trends in Immunology

      Volume: 41 Issue: 5 Pages: 394-405

    • DOI

      10.1016/j.it.2020.03.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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