| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Mast cells are primary effectors not only in allergic disorders, but also in other immune diseases such as chronic inflammatory disorders. Mast cells are generally classified into two phenotypically distinct populations: mucosal-type mast cells (MMCs) and connective tissue-type mast cells (CTMCs). However, the molecular basis determining the different characteristics of the mast cell subclasses still remains unclear. In this study, we generate knock-out (KO) mice and analyze the number of mast cells in the KO mice. Our results showed that the number of mast cell progenitors and CTMCs was decreased in KO mice. In addition, engraftment of WT bone marrow cells in w-sh/w-sh recipients restored the generation of CTMCs to normal levels. In contrast, engraftment of KO bone marrow cells in w-sh/w-sh mice failed to restore mast cell generation. These results showed that differentiation of CTMCs might be regulated by Gfi1.
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