Identification of a novel deubiquitinating enzyme that controls epithelial-mesenchymal transition and its application to cancer treatment.
| Project/Area Number |
18K06660
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
|
|---|
| Research Institution | Nagoya City University |
|---|
Principal Investigator |
Inoue Yasumichi 名古屋市立大学, 医薬学総合研究院(薬学), 准教授 (10450579)
|
|---|
| Project Period (FY) |
2018-04-01 – 2021-03-31
|
| Project Status |
Completed (Fiscal Year 2020)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 上皮間葉転換 / 脱ユビキチン化酵素 / 転移 / 阻害剤 / 浸潤・転移 / Warburg効果 / がん幹細胞 |
|---|
| Outline of Final Research Achievements |
Epithelial-mesenchymal transition (EMT) is involved in malignant transformation of cancer including infiltration and metastasis of cancer. Therefore, clarifying the control mechanism of EMT is important in developing new cancer treatment strategies. In this study, we identified a novel deubiquitinating enzyme for transcription factors (Snail, Twist, c-Myc, etc) that regulate EMT and clarified the molecular mechanism of carcinogenesis and metastasis of cancer.
|
| Academic Significance and Societal Importance of the Research Achievements |
近年、がんの診断・治療法の進歩で、患者が原発がんによって死亡することは少なくなり、現在のがん治療研究の標的も他臓器転移へと移りつつある。しかしいまだに、がんが一度、転移・再発すると、現在用いられている化学療法のほとんどは無効で、新たながん転移の予防または抑制を可能にする治療法の開発が急務である。本研究では、一連のEMT関連転写因子に対する脱ユビキチン化酵素を同定し、EMT誘導ならびにがんの浸潤・転移における分子メカニズムを明らかにした。本研究成果から、脱ユビキチン化酵素阻害剤ががん転移を抑制する新規治療薬として開発促進につながることが期待できる。
|
Report
(4 results)
Research Products
(36 results)
-
-
-
[Journal Article] A novel regulatory mechanism against BMP/Smad signaling by Smurf2 in bone2020
Author(s)
Junichi Kushioka, Takashi Kaito, Rintaro Okada, Hiroyuki Ishiguro, Zeynep Bal, Joe Kodama, Ryota Chijimatsu, Melanie Pye, Masahiro Narimatsu, Jeffrey Wrana, Yasumichi Inoue, Hiroko Ninomiya, Shin Yamamoto, Takashi Saitou, Hideki Yoshikawa, Takeshi Imamura
-
Journal Title
Bone Research
Volume: 8
Issue: 1
Pages: 41-41
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 苦参由来成分kurarinone は統合的ストレス応答 PERK-ATF4 経路を活性化しがん細胞の増殖を抑制 する2021
Author(s)
德川宗成, 西川佐紀子, 伊藤友香, 井上靖道, 中島健一, 堀優華, 宮嶋ちはる, 井上誠, 水上元, 牧野利明, 林秀敏
Organizer
日本薬学会第141年会
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
