| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Cancer stem cells (CSCs) are self-renewing cancer cells that have been implicated in cancer recurrence and resistance to therapy and are considered promising targets for cancer therapy. The hexosamine biosynthetic pathway (HBP) is emerging as a nutrient sensor that integrates nutrient availability with numerous intracellular signaling networks. In this study, we investigated the role of HBP and its downstream signaling in CSC regulation and found that HBP flux comprehensively regulates CSC-like features by driving hyaluronan and O-GlcNAcylation signaling pathways. Furthermore, we found that hyaluronan signaling triggers the Akt/GSK3β/β-catenin signaling pathway and promotes cell survival and drug-resistance.
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