| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The stress response contributes to cellular homeostasis by expressing heat shock proteins (Hsp). However, Hsp causes resistance to heat stress and anticancer drugs in cancer cells. In this study, we showed the involvement of Stat3 and Hsp105 in the acquisition of thermotolerance of cancer cells. Since Stat3 activation contributes to cancer cell survival and metastasis, we investigated how heat stress possibly induces enhanced metastatic invasion and epithelial-mesenchymal transition. Cell migration assay and western blot analysis suggested that heat shock increases the number of migrating cells and the involvement of Stat3 phosphorylation in the heat shock-induced cancer cell migration.
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