| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
Anti-inflammatory related proteins (Thioredoxin-like protein 1, Latexin) expression were incleased in exosomes derived human nerve cells on 4-methoxy amphetamine (4-MeO AP) abuse group compare to AP group. Moreover, phosphatidylcholines containing docosahexaenoic acids were reduced in exosomes derived human nerve cells on 4-MeO AP abuse group compare to AP group. In this study, we showed the difference inflammatory response induced by nerve cell-derived exosomes depends on the types of drugs.
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