| Project/Area Number |
18K06676
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 乳がん / 亜鉛 / 亜鉛トランスポーター / がん幹細胞様細胞 / PRDM14 / 低酸素 / HIF-1 / MTA-1 / 乳がん幹細胞 / 低酸素環境 / 悪性化進展 / ストレス応答性 |
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| Outline of Final Research Achievements |
Breast cancer stem cell-like cells (BCSCs) lurk in very few populations within breast cancer tissues and can give rise to metastasis, recurrence, and drug resistance after a long period of time, contributing to poor clinical outcomes. We demonstrated that zinc is required to maintain BCSCs. Moreover, the mechanisms underlying the maintenance of BCSCs are regulated by zinc dependent PR domain zinc finger protein 14 (PRDM14) function through zinc transporters ZIP6 and ZIP7.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで謎に包まれていた乳がん幹細胞様細胞の維持機構において、亜鉛および亜鉛トランスポーターの関与を初めて明らかにし、本研究成果は、乳がん悪性化機構の本態解明に重要な方向性を示すものである。さらに、亜鉛ネットワークを利用した乳がん診断マーカーの開発や新たな乳がん治療方法の確立への道を切り開く突破口として、実用化に向けての貢献が期待される。
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