| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
We investigated the effect of a novel nucleic acid compound that specifically inhibits chymase on heart failure after myocardial infarction. Cardiac chymase activity was significantly increased after myocardial infarction, but it was significantly suppressed by the nucleic acid compound. Cardiac mRNA levels of TGF-β and collagen increased after myocardial infarction were significantly reduced by the nucleic acid compound. Cardiac function reduced after myocardial infarction was also significantly improved by the nucleic acid preparation, and the mortality rate was significantly reduced. The nucleic acid compound with specific chymase inhibition was useful in the prevention of heart failure after myocardial infarction.
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