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Search for tubulin regulatory molecules and elucidate the site of active expression for the creation of novel anticancer drugs

Research Project

Project/Area Number 18K06718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47050:Environmental and natural pharmaceutical resources-related
Research InstitutionNagasaki University

Principal Investigator

YAMADA Koji  長崎大学, 医歯薬学総合研究科(薬学系), 准教授 (00253469)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsチューブリン分子 / 海洋無脊椎動物 / 海綿動物 / 海草 / AChE阻害活性阻害 / H5N1ウイルス増殖抑制 / 抗がん剤 / PC12
Outline of Final Research Achievements

In this study, in order to search for components exhibiting tubulin polymerization / depolymerization inhibitory activity from marine invertebrates and develop the obtained components as seed compounds for new anticancer agents, collection of marine organisms and active constituents was separated. Specifically, each sample animal collected and the microbial culture were processed to prepare a crude extract. As the first screening, we investigated the neurite outgrowth effect on PC12 cells in the presence of nerve growth factor for each crude extract, and showed a neurite outgrowth effect, which may affect tubulin function. Extracts were selected and the active ingredient was isolated. As a result, ceramides, cerebrosides, and cyclic peptides could be isolated from seaweeds, sponges, and marine bacteria and their structures determined.

Academic Significance and Societal Importance of the Research Achievements

がん克服を実現するためには、化学療法で用いられる有効な新規抗がん剤を創出することが不可欠である。そのためには、抗がん剤開発の鍵となるシード化合物の創成が求められる。本研究において、海洋無脊椎動物からシード化合物になりうる活性成分を検索することを目的として実施し、海綿動物、海草、海洋微生物から活性成分を分離することに成功したことは学術的に意義深く、将来医薬開発の糸口になりえる点で社会的意義が大きい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (16 results)

All 2021 2020 2019 2018

All Journal Article (12 results) (of which Int'l Joint Research: 12 results,  Peer Reviewed: 12 results,  Open Access: 12 results) Presentation (4 results)

  • [Journal Article] Chemical Constituent Profiling of Phyllostachys heterocycla var. Pubescens with Selective Cytotoxic Polar Fraction through EGFR Inhibition in HepG2 Cells2021

    • Author(s)
      Reda F. A. Abdelhameed , Eman S. Habib, Ahmed K. Ibrahim, Koji Yamada, Maged S. Abdel-Kader, Safwat A. Ahmed, Amany K. Ibrahim, Jihan M. Badr and Mohamed S. Nafie
    • Journal Title

      Molecules

      Volume: 26 Issue: 4 Pages: 940-952

    • DOI

      10.3390/molecules26040940

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytotoxic, Apoptosis-Inducing Activities, and Molecular Docking of a New Sterol from Bamboo Shoot Skin Phyllostachys heterocycla var. pubescens2020

    • Author(s)
      Reda F. A. Abdelhameed, Mohamed S. Nafie , Ahmed K. Ibrahim, Koji Yamada , Maged S. Abdel-Kader, Amany K. Ibrahim, Safwat A. Ahmed, Jihan M. Badr and Eman S. Habib
    • Journal Title

      Molecules

      Volume: 25 Issue: 23 Pages: 5650-5664

    • DOI

      10.3390/molecules25235650

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel Reporter System Monitoring IL-18 Specific Signaling Can Be Applied to High-Throughput Screening2020

    • Author(s)
      Kurata R, Shimizu K, Cui X, Harada M, Isagawa T, Semba H, Ishihara J, Yamada K, Nagai J, Yoshida Y, Takeda N, Maemura K, Yonezawa T.
    • Journal Title

      Marine Drugs

      Volume: 18 Issue: 1 Pages: 60-60

    • DOI

      10.3390/md18010060

    • NAID

      120006988310

    • Related Report
      2020 Annual Research Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pentabromobenzyl-RP versus triazole-HILIC columns for separation ofthe polar basic analytes famotidine and famotidone: LC methoddevelopment combined with in silico tools to follow the potentialconsequences of famotidine gastric instability2020

    • Author(s)
      Rania El-Shahenya, Mohamed O. Radwanc,d,e,, Fathalla Belala, Koji Yamada
    • Journal Title

      Journal of Pharmaceutical and Biomedical Analysis

      Volume: 186 Pages: 113305-113317

    • DOI

      10.1016/j.jpba.2020.113305

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New Cytotoxic Natural Products from the Red Sea Sponge Stylissa carteri2020

    • Author(s)
      Abdelhameed Reda F. A.、Habib Eman S.、Eltahawy Nermeen A.、Hassanean Hashim A.、Ibrahim Amany K.、Mohammed Anber F.、Fayez Shaimaa、Hayallah Alaa M.、Yamada Koji、Behery Fathy A.、Al-Sanea Mohammad M.、Alzarea Sami I.、Bringmann Gerhard、Ahmed Safwat A.、Abdelmohsen Usama Ramadan
    • Journal Title

      Marine Drugs

      Volume: 18 Issue: 5 Pages: 241-241

    • DOI

      10.3390/md18050241

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Toward a treatment of diabesity: Rational design, synthesis and biological evaluation of benzene-sulfonamide derivatives as a new class of PTP-1B inhibitors.2019

    • Author(s)
      Ghareb N, El-Sayed NM, Abdelhameed R, Yamada K, Elgawish MS.
    • Journal Title

      Bioorganic Chemistry

      Volume: 27 Pages: 322-338

    • DOI

      10.1016/j.bioorg.2019.01.052

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Production of a New Cyclic Depsipeptide by the Culture Broth of Staphylococcus sp. Isolated from Corallina ocinalis L.2019

    • Author(s)
      Reda F. A. Abdelhameed, Sameh S. Elhady, Ahmad O. Noor, Diena M. Almasri, Alaa A. Bagalagel, Galal T. Maatooq, Amgad I. M. Khedr and Yamada K
    • Journal Title

      Metabolites

      Volume: 2019 Issue: 11 Pages: 273-281

    • DOI

      10.3390/metabo9110273

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new Iridodi Glucoside from Anisacanthus virgularis and Its Antiamoebic Activity2019

    • Author(s)
      Mohamed S. Refaey, Reda A. Abdelhamid, Mohamed A. A. Orabi, Ahmmed A. Ali, Reda Fouad Ahmed Abdelhameed, Eman A. A. Mousa, Shinjiro Hamano, and Yamada K
    • Journal Title

      Heterocycles

      Volume: 98 Pages: 1229-1235

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Estimation of nizatidine gastric nitrosatability andproduct toxicity via an integrated approachcombining HILIC, in silico toxicology, andmolecular docking2019

    • Author(s)
      Rania El-Shaheny, Mohamed Radwan, Yamada K and Mahmoud El-Maghrabey
    • Journal Title

      Journal of Food and Drug Analysis

      Volume: 27 Issue: 4 Pages: 915-925

    • DOI

      10.1016/j.jfda.2019.08.001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cytotoxic and anti-inflammatory compounds from Red Sea grass Thalassodendron ciliatum2018

    • Author(s)
      Abdelhameed, R.F., Ibrahim, A.K., Yamada K, Ahmed, S.A
    • Journal Title

      Medicinal Chemistry Research

      Volume: 27 Issue: 4 Pages: 1238-1244

    • DOI

      10.1007/s00044-018-2143-7

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Panduramides A-D, new ceramides from Ficus pandurata fruits2018

    • Author(s)
      Amgad I.M.Khedra, Sabrin R.M.Ibrahimbc, Gamal A.Mohamedde, Samir A.Rossf, Yamada K
    • Journal Title

      Phytochemistry Letters

      Volume: 23 Pages: 100-105

    • DOI

      10.1016/j.phytol.2017.11.023

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Chemical studies on the parasitic plant Thonningia sanguinea Vahl,2018

    • Author(s)
      Ama Kyeraa Thomford, Reda Fouad Ahmed Abdelhameed and Yamada K
    • Journal Title

      RSC Advances

      Volume: 2018 Issue: 37 Pages: 21002-21011

    • DOI

      10.1039/c8ra03913e

    • NAID

      120006988038

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ガーナ産植物(Thonningia sanguinea Vahl) の成分研究(第2報)2021

    • Author(s)
      池本瑞季、Ama K. Thomford、Reda F. A. Abdelhameed、山田耕史
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Anisacanthus vigularis 由来の生物活性成分に関する化学的研究(第1報)~イリドイド配糖体について~2020

    • Author(s)
      Mohamed S. Refaey、池本瑞季、Reda A. Abdelhamid、Mohamed A. A. Orabi、 Ahmed A. Ali、Reda Fouad Ahmed Abdelhameed、Eman A. A. Mousa、濱野真二郎、山田耕史
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 長崎県産トウゲシバ(Huperzia serrata)の成分研究(第2報)2019

    • Author(s)
      香田沙羅、日下世菜、出田智明、森崎弘司、岩崎一成、山田耕史
    • Organizer
      第36回日本薬学会九州支部大会
    • Related Report
      2019 Research-status Report
  • [Presentation] マナマコ由来セレブロシドの血清コレステロール代謝改善作用のメカニズム2018

    • Author(s)
      渡辺 彩子、武田 美優、梅木 美樹、 山田 耕史、望月 聡、小田 裕昭
    • Organizer
      第72回日本栄養・食糧学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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