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Development for neuronal stem cells control compounds using molecular networking

Research Project

Project/Area Number 18K06727
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47050:Environmental and natural pharmaceutical resources-related
Research InstitutionTokushima Bunri University

Principal Investigator

Kubo Miwa  徳島文理大学, 薬学部, 准教授 (00330754)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords神経栄養因子様活性物質 / PC12細胞 / Gmelina arborea / 神経栄養因子 / 神経幹細胞 / モレキュラーネットワーキング / メタボロミクス / 天然物メタボロミクス
Outline of Final Research Achievements

As a primary screening for the discovery of neurotrophic factor-like active substances, the BS test (BST) was applied to screen a library of about 600 plants from Myanmar. As a result, I found that several plant species including Gmelina arborea belonging to the Perillaceae family showed BST activity and they exhibited neurotrophic factor-like activity against PC12 cells. I found that BST, which can be easily performed by anyone, is useful as a primary screening tool to search for neurotrophic factor-like active substances.

Academic Significance and Societal Importance of the Research Achievements

創薬の初期を担う1次スクリーニングは,安価で,簡便且つ迅速であることが望ましい。本研究では,誰もができるブラインシュリンプアッセイを用いて,世界が渇望するアルツハイマー型認知症の根本的治療予防薬開発を指向した,神経可塑性賦活化剤である神経栄養因子様活性物質探索のための簡便なフェノタイプ型ハイスループットスクリーニングを構築し,天然物メタボロミクスを活用した高効率的な化合物精製法と統合した次世代型天然物創薬の発展へ繋がる結果を得ることができた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (23 results)

All 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (9 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (12 results) (of which Int'l Joint Research: 5 results) Remarks (1 results)

  • [Int'l Joint Research] University of Geneva(スイス)

    • Related Report
      2018 Research-status Report
  • [Journal Article] cis-Banglene, a bangle (Zingiber purpureum)-derived bioactive compound, promotes mitochondrial biogenesis and glucose uptake by activating the IL-6/AMPK signaling pathway in C2C12 skeletal muscle cells.2020

    • Author(s)
      Norikura T, Kajiya S, Sugawara M, Kubo M, Fukuyama Y, Sato S.
    • Journal Title

      Journal of Functional Foods

      Volume: 64 Pages: 103632-103632

    • DOI

      10.1016/j.jff.2019.103632

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemistry and Neurotrophic Activities of (?)-Talaumidin and Its Derivatives2020

    • Author(s)
      Harada Kenichi、Kubo Miwa、Fukuyama Yoshiyasu
    • Journal Title

      Frontiers in Chemistry

      Volume: 8 Pages: 301-301

    • DOI

      10.3389/fchem.2020.00301

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Indonesian ginger (Bangle) extract promotes neurogenesis of human neural stem cells through WNT pathway activation2020

    • Author(s)
      Hirano, Kazumi; Kubo, Miwa; Fukuyama, Yoshiyasu; Namihira, Masakazu
    • Journal Title

      International journal of molecular Scienceses

      Volume: 21 Issue: 13 Pages: 4772-4772

    • DOI

      10.3390/ijms21134772

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolite Profiling of Javanese Ginger Zingiber purpureum and Identification of Antiseizure Metabolites via a Low-Cost Open-Source Zebrafish Bioassay-Guided Isolation2020

    • Author(s)
      Brillatz Th?o、Kubo Miwa、Takahashi Shimon、Jozukuri Natsumi、Takechi Kenshi、Queiroz Emerson Ferreira、Marcourt Laurence、Allard Pierre-Marie、Fish Richard、Harada Kenichi、Ishizawa Keisuke、Crawford Alexander D.、Fukuyama Yoshiyasu、Wolfender Jean-Luc
    • Journal Title

      Journal of Agricultural and Food Chemistry

      Volume: 68 Issue: 30 Pages: 7904-7915

    • DOI

      10.1021/acs.jafc.0c02641

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Taxonomically Informed Scoring Enhances Confidence in Natural Products Annotation.2019

    • Author(s)
      A. Rutz, M. Dounoue-Kubo, S. Ollivier, J. Bission, M. Saesong, S. N. Ebrahimi, K. Ingkaninan, J.-L. Wolfender, P.-M. Allard.
    • Journal Title

      Front. Plant. Sci

      Volume: 10 Pages: 1329-1329

    • DOI

      10.3389/fpls.2019.01329

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Metabolomics strategies for the dereplication of polyphenols and other metabolites in complex natural extracts2019

    • Author(s)
      J.-L. Wolfender, P.-M. Allard, M. Kubo, E. F. Queiroz
    • Journal Title

      Recent Advances in Polyphenol Research

      Volume: 6 Pages: 183-205

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structure-activity relationships of talaumidin derivatives: Their neurite-outgrowth promotion in vitro and optic nerve regeneration in vivo.2018

    • Author(s)
      K. Harada, K. Zaha, R. Bando, R. Irimaziri, M. Kubo, Y. Koriyama, Y. Fukuyama.
    • Journal Title

      Eur. J. Med. Chem.

      Volume: 148 Pages: 86-94

    • DOI

      10.1016/j.ejmech.2018.02.014

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Talaumidin promotes neurite outgrowth of staurosporine-differentiated RGC-5 cells through PI3K/Akt-dependent pathway2018

    • Author(s)
      Y. Koriyama, A. Furukawa, K. Sugitani, M. Kubo, K. Harada, Y. Fukuyama
    • Journal Title

      Adv. Exp. Med. Biol

      Volume: 1074 Pages: 649-653

    • DOI

      10.1007/978-3-319-75402-4_79

    • ISBN
      9783319754017, 9783319754024
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Safety assessment of Bangle(Zingiber purpureum Rosc.) rhizome extract: Acute and chronic studies in rats and clinical studies in human.2018

    • Author(s)
      E. Kato, M. Kubo, Y. Okamoto, Y. Matsunaga, H. Kyo, N. Suzuki, K. Uebara, Y. Fukuyama.
    • Journal Title

      ACS Omega

      Volume: 3 Issue: 11 Pages: 15879-15889

    • DOI

      10.1021/acsomega.8b02485

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] ジャワショウガ Bangleの歯周病原菌増殖抑制抑制活性成分の探索研究2020

    • Author(s)
      矢野渚,山内学,古江由依,原田研一,久保美和,小田真隆,福山愛保
    • Organizer
      日本薬学会第140年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 三成分縮合反応を利用したアマラステリンAの合成研究2020

    • Author(s)
      久米貴大,高橋賢龍,原田研一,久保美和,大崎愛弓,福山愛保
    • Organizer
      日本薬学会第140年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 二連続四級炭素構築法を利用したフラノピングイサノールの合成研究2020

    • Author(s)
      大上南波,原田研一,大西菜月,板東裕大,久保美和,福山愛保
    • Organizer
      日本薬学会第140年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 殺ブラインシュリンプ活性を1次スクリーニングとして活用したミャンマー産植物Gmelina arborea に含まれる神経栄養因子様活性成分の探索研究とメタボロミクス解析2020

    • Author(s)
      久保美和,入交諒,川田美都紀,林佳菜,松野倫代,幾井康仁,原田研一,水上元,福山愛保
    • Organizer
      第62回天然有機化合物討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 殺ブラインシュリンプ活性を有するミャンマー産植物Gmelina arboreaの化学成分研究2019

    • Author(s)
      入交諒,川田美都紀,松野倫代,幾井康仁,原田研一,久保美和,水上元,福山愛保
    • Organizer
      第63回香料・テルペンおよび精油化学に関する討論会
    • Related Report
      2019 Research-status Report
  • [Presentation] PRIORITIZATION OF HIGH-VALUE NATURAL PRODUCTS FROM A LARGE CHEMO-DIVERSE PLANT EXTRACTS COLLECTION: A FOCUS ON STRUCTURAL NOVELTY2019

    • Author(s)
      Luis Quiros-Guerrero, Arnaud Gaudry, Adriano Rutz, Miwa Dounoue, Marcel Kaiser, Emerson Ferreira Queiroz, Laurence Marcourt, Bruno David, Jean-Luc Wolfender, Pierre-Marie Allard
    • Organizer
      GA2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Taxonomically informed metabolite annotation2019

    • Author(s)
      Adriano Rutz, Miwa Dounoue-Kubo, Simon Ollivier, Jonathan Bisson, Mohsen Bagheri, Tongchai Saesong, Samad Nejad Ebrahimi, Kornkanok Ingkaninan, Jean-Luc Wolfender, Pierre-Marie Allard
    • Organizer
      GA2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] MULTI-INFORMATIVE BIOACTIVITY-BASED MOLECULAR NETWORKING OF A LARGE CHEMODIVERSE PLANT COLLECTION ALLOWS EFFICIENT IDENTIFICATION OF TRYPANOCIDAL NATURAL PRODUCTS2019

    • Author(s)
      Arnaud Gaudry, Luis Manuel Quiros Guerrero, Adriano Rutz, Miwa Dounoue, Marcel Kaiser, Bruno David, Emerson Ferreira Queiroz, Laurence Marcourt, Jean-Luc Wolfender, Pierre-Marie Allard
    • Organizer
      GA2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] ゼブラフィッシュアッセイを基盤としたジャワショウガBangleに含まれる抗痙攣作用物質の同定とモレキュラーネットワークプロファイリング2019

    • Author(s)
      久保美和,Theo Brillatz, Emerson Ferreira Queiroz, Pierre-Marie Allard,原田研一,加藤栄信,細田真也,Jean-Luc Wolfender,福山愛保
    • Organizer
      日本薬学会第138年会
    • Related Report
      2018 Research-status Report
  • [Presentation] Contextualized Metabolomics Transforms Pharmacognosy; A Paradigm Shift in Natural Product Research2018

    • Author(s)
      Jean-Luc Wolfender, Miwa Dounoue Kubo, Emerson Ferreira Queiroz, Pierre-Marie Allard
    • Organizer
      GA2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] ミャンマー産植物に関する研究 (2) ;クマツヅラ科植物 Gmelina arborea茎の成分研究–2018

    • Author(s)
      川田美都紀、入交諒、松野倫代、原田研一、久保美和、水上元、福山愛保
    • Organizer
      第57回日本薬学会中国四国支部学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Neurotrophic Compounds from Javanese Ginger Bangle, Zingiber purpureum2018

    • Author(s)
      Y. Fukuyama, M. Kubo, M. Nakai, K. Harada, N. Matsui, M. Suenaga, Y. Matsunaga, M. Miyamura, E. Kato
    • Organizer
      ISCNP30-ICOB10
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Remarks] 徳島文理大学薬学部薬品物理化学教室

    • URL

      http://p.bunri-u.ac.jp/lab02/fukuyama/index.htm

    • Related Report
      2019 Research-status Report 2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-01-27  

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