| Project/Area Number |
18K06727
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
Kubo Miwa 徳島文理大学, 薬学部, 准教授 (00330754)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経栄養因子様活性物質 / PC12細胞 / Gmelina arborea / 神経栄養因子 / 神経幹細胞 / モレキュラーネットワーキング / メタボロミクス / 天然物メタボロミクス |
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| Outline of Final Research Achievements |
As a primary screening for the discovery of neurotrophic factor-like active substances, the BS test (BST) was applied to screen a library of about 600 plants from Myanmar. As a result, I found that several plant species including Gmelina arborea belonging to the Perillaceae family showed BST activity and they exhibited neurotrophic factor-like activity against PC12 cells. I found that BST, which can be easily performed by anyone, is useful as a primary screening tool to search for neurotrophic factor-like active substances.
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| Academic Significance and Societal Importance of the Research Achievements |
創薬の初期を担う1次スクリーニングは，安価で，簡便且つ迅速であることが望ましい。本研究では，誰もができるブラインシュリンプアッセイを用いて，世界が渇望するアルツハイマー型認知症の根本的治療予防薬開発を指向した，神経可塑性賦活化剤である神経栄養因子様活性物質探索のための簡便なフェノタイプ型ハイスループットスクリーニングを構築し，天然物メタボロミクスを活用した高効率的な化合物精製法と統合した次世代型天然物創薬の発展へ繋がる結果を得ることができた。
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