| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The search of the new natural organic compounds and analysis of their biochemical characters for development of the therapeutic drug against adult T-cell leukemia. For treatment of adult T cell leukemia (ATL) that is one of the intractable diseases, the development of the newly anticancer agents which have unique action mechanism are demanded. Using the technique that we used by a search process of newly anticancer agent candidate compound hyptoside, we searched for a new lead compound for ATL from marine organisms and plants in Japan and Malaysia.
As a result, we isolated 41 kinds of anti-ATL compounds having carbon skeleton unlike hyptoside and determined their chemical structure using nuclear magnetic resonance (NMR) techniques mainly. Among them, eight compounds are new and will try to do the structure active relationship study and clarify their action mechanism in future soon.
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