The search of the new natural organic compounds and analysis of their biochemical characters for development of the therapeutic drug against adult T-cell leukemia.
| Project/Area Number |
18K06732
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 成人T細胞白血病 / 抗がん剤 / 植物 / 海綿 / 海藻 / ソフトコーラル / 薬用植物 / 紅藻 / 天然物化学 / 海洋無脊椎動物 |
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| Outline of Final Research Achievements |
The search of the new natural organic compounds and analysis of their biochemical characters for development of the therapeutic drug against adult T-cell leukemia. For treatment of adult T cell leukemia (ATL) that is one of the intractable diseases, the development of the newly anticancer agents which have unique action mechanism are demanded. Using the technique that we used by a search process of newly anticancer agent candidate compound hyptoside, we searched for a new lead compound for ATL from marine organisms and plants in Japan and Malaysia.
As a result, we isolated 41 kinds of anti-ATL compounds having carbon skeleton unlike hyptoside and determined their chemical structure using nuclear magnetic resonance (NMR) techniques mainly. Among them, eight compounds are new and will try to do the structure active relationship study and clarify their action mechanism in future soon.
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| Academic Significance and Societal Importance of the Research Achievements |
ATLは国内のみでなく、東南アジア、北米、中南米、オセアニア、アフリカにも感染者が分布しており、患者数は依然として増え続けている。一方、この難病に対する治療法の開発は、最近になって日本で本腰を入れて研究を進められているが、国外ではほとんど進んでいない。
本研究によって、ATLのみならず、多くの癌の治療方法が改善されること、また、多剤耐性を克服しうる多くの薬剤が開発されることを期待する。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Involvement of ribosomal protein L11 expression in sensitivity of gastric cancer against 5?FU2020
Author(s)
Kawahata T, Kawahara K, Shimokawa M, Sakiyama A, Shiraishi T, Minami K, Yamamoto M, Shinsato Y, Arima K, Hamada T, Furukawa T.
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Journal Title
Oncology Letters
Volume: 19
Pages: 2258-2264
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Identification of Ribosomal Protein L11 as a Novel Biomarker of 5-FU Sensitivity for Gastric Cancer.2019
Author(s)
Takuto Kawahata, kohichi Kawahara, Michiko Shimokawa, Akie Sakiyama, Takehiro Shiraishi, Kentaro Minami, Masatatsu Yamamoto, Yoshinari Shinsato, Kazunari Arima, Toshiyuki Hamada, Tatsuhiko Furukawa
Organizer
ICBMB 2019 (International Conference on Biochemistry and Molecular Biology)
Related Report
Int'l Joint Research
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