Discovery of the seeds for novel cancer molecular-targeted agents from plant-derived steroid compounds
| Project/Area Number |
18K06735
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47050:Environmental and natural pharmaceutical resources-related
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ステロイド / がん分子標的 / アポトーシス / ミトコンドリア / 細胞周期 / 細胞毒性 / 微小管 / 紡錘体 |
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| Outline of Final Research Achievements |
Fifty steroidal compounds including new compounds were isolated from Ranunculaceae, Poaceae, and Apocynaceae plants for the purpose of searching for new seed compounds of cancer molecular-targeted agents. Among them, steroidal compounds isolated from the genus Helleborus (Ranunculaceae) had potent cytotoxicity to human cancer cells, and induced apoptosis by a mitochondrial mediated pathway and arrested cell cycle progression in G2/M phase in human leukemia cells.
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| Academic Significance and Societal Importance of the Research Achievements |
現在まで細胞毒性メカニズムの詳細が明らかにされていない植物由来のステロイド化合物に着目して、既存の抗がん剤の問題点を克服する医薬シーズの探索研究に着手した。本研究により、腫瘍細胞に対して細胞分裂期で細胞周期を停止する傾向を示すとともにアポトーシスを誘導する新規植物由来ステロイドを見出した。それらの化合物は、ヒト腫瘍細胞の細胞分裂期のがん細胞に作用する新規がん分子標的治療薬シーズとして今後の研究の展開が期待され、学術的意義や社会的意義は大きいと考えられる。
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Report
(4 results)
Research Products
(17 results)
