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Studies on the induction of secondary metabolites in medicinal plants of the Apiaceae family using insect-derived elicitors

Research Project

Project/Area Number 18K06738
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47050:Environmental and natural pharmaceutical resources-related
Research InstitutionRitsumeikan University

Principal Investigator

Tanaka Ken  立命館大学, 薬学部, 教授 (60418689)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords化学生態学 / 生薬学 / 昆虫植物相互作用 / セリ科薬用植物
Outline of Final Research Achievements

Papilio machaon hippocrates larvae are pests of plants of the family Apiaceae. LC-MS analysis of the regurgitant of P. machaon hippocrates larvae revealed a great increase in α-linolenic acid (α-LA) in the regurgitant compared with the FAs contained in the leaves. After α-LA treatment to leaves, induced defensive reactions, i.e., release of volatile compounds such as α- pinene (possible induced indirect defense) and the accumulation of secondary metabolites such as falcarinol and bergapten (possible induced direct defense) were observed. These findings highlight the role of α-LA in the interaction between P. machaon hippocrates larvae and Apiaceae host plants.

Academic Significance and Societal Importance of the Research Achievements

これまでアゲハ属のチョウ類の幼虫が含有するエリシター化合物は特定されていなかった。そこで、種々のセリ科植物を食害しているキアゲハ幼虫の吐き戻し液を採取し、含有成分を網羅的に検索して、キアゲハ幼虫が有するエリシター化合物を明らかにした。さらに、このエリシター化合物がセリ科薬用植物の有用な二次代謝物の産生を誘導することを明らかにし、高品質の薬用植物を効率的に増産するための新たな栽培法として、植物の化学生態学的応答を利用した方法を提示することができた。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] α-Linolenic acid in Papilio machaon larvae regurgitant induces a defensive response in Apiaceae2021

    • Author(s)
      Yuto Nishidono, Kotaro Niwa, Aoi Kitajima, Shiro Watanabe, Yasuhiro Tezuka, Masanori Arita, Junji Takabayashi, Ken Tanaka
    • Journal Title

      Phytochemistry

      Volume: -

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efect of heat processing on the chemical constituents and NO-suppressing activity of Bletilla Tuber2020

    • Author(s)
      Nishidono Y., Ishii T., Okada R., Norimoto H., Murayama C., He D., Okuyama T., Nishizawa M., Tanaka K.
    • Journal Title

      Journal of Natural Medicines

      Volume: 74 Issue: 1 Pages: 219-228

    • DOI

      10.1007/s11418-019-01371-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Anti-inflammatory kavalactones from Alpinia zerumbet2020

    • Author(s)
      Nishidono Yuto、Okada Ryo、Iwama Yuuna、Okuyama Tetsuya、Nishizawa Mikio、Tanaka Ken
    • Journal Title

      Fitoterapia

      Volume: 140 Pages: 104444-104444

    • DOI

      10.1016/j.fitote.2019.104444

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Analysis of Seasonal Variations of the Volatile Constituents in Artemisia princeps (Japanese Mugwort) Leaves by Metabolomic Approach2019

    • Author(s)
      Nishidono Yuto、Chiyomatsu Takahiro、Sanuki Kazuyuki、Tezuka Yasuhiro、Tanaka Ken
    • Journal Title

      Natural Product Communications

      Volume: 14 Issue: 8 Pages: 1-8

    • DOI

      10.1177/1934578x19872600

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of in vitro germination method for Apiaceae plant.2020

    • Author(s)
      Niwa K, Kitajima A, Nishidono Y, Sawa K, Tanaka K
    • Organizer
      The 11th International Conference on Global Resource Conservation (ICGRC)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 昆虫-植物相互作用を利用した薬用植物の機能性強化に関する研究 12020

    • Author(s)
      丹羽浩太郎, 北嶋葵, 西殿悠人, 澤一輝, 有田正規, 田中謙
    • Organizer
      日本植物学会第84回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 昆虫-植物相互作用を利用した薬用植物の機能性強化に関する研究22020

    • Author(s)
      北嶋葵, 丹羽浩太郎, 西殿悠人, 澤一輝, 有田正規, 田中謙
    • Organizer
      日本植物学会第84回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 滋賀県産ヨモギArtemisia princeps Pamp.の葉に含まれる香気成分の季節変動2020

    • Author(s)
      西殿 悠人、千百松 崇大、讃岐 和幸、田中 謙
    • Organizer
      日本薬学会第104年会
    • Related Report
      2019 Research-status Report
  • [Presentation] 塩ストレス条件下におけるカンゾウのグリチルリチン生合成能解析2019

    • Author(s)
      中本 雅俊, 金田 理子, 西殿 悠人, 柏原 彩帆, 手塚 康弘, 田中 謙
    • Organizer
      日本薬学会第139年会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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