| Project/Area Number |
18K06756
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | National Institute of Health Sciences (2020)
Kitasato University (2018-2019) |
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Principal Investigator |
Tanaka Yoichi 国立医薬品食品衛生研究所, 医薬安全科学部, 主任研究官 (40525341)
|
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 6-メルカプトプリン / 白血病 / 小児 / DNA / deoxy thioguanosine / NUDT15 / LC-MS/MS / deoxy thioguanine / DNA-dTG / 小児白血病 / メルカプトプリン / 代謝物 / 濃度 |
|---|
| Outline of Final Research Achievements |
To adjust 6-mercaptopurine (6-MP) therapy for children with acute lymphoblastic leukemia, we measured 6-MP metabolite in blood cells and DNA during maintenance therapy and evaluated the association among 6-MP metabolite levels, genetic variations of 6-MP metabolism enzymes and 6-MP dose. 6-MP metabolite levels were associated with 6-MP intolerability in each cells. And 6-MP metabolite level inserted into DNA was influence on NUDT15 genetic variants.
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| Academic Significance and Societal Importance of the Research Achievements |
小児急性リンパ性白血病における6-MPによる治療の感受性には、DNAに取り込まれた6-MP代謝物量が関連している。また患者の持つNUDT15遺伝子多型によって、DNAへの取り込まれやすさが異なる。患者の持つNUDT15遺伝子多型および6-MP代謝物濃度の測定を併せて検討する事で、治療効果が期待できるが副作用が少ない患者個々に合わせた6-MPによる治療を提供することができると考えられる。
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