| Project/Area Number |
18K06768
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高井 真司 大阪医科大学, 医学研究科, 教授 (80288703)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | バイオマーカ－ / 食塩感受性高血圧 / 慢性腎臓病 / Dahl salt-sensitive rat / 臨床研究 / 非侵襲性 / 慢性腎臓病（CKD） / 尿細管障害 / バイオマーカー / 尿細管 / 食塩過剰摂取 / 高血圧 / 基礎研究 / 腎障害 / 食塩 / 腎線維化 |
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| Outline of Final Research Achievements |
In basic study, a high-salt intake to Dahl salt-sensitive (DS) caused elevated blood pressure, histological renal tubular damages, and increase in renak MDA and urinary vanin-1, both of which were suppressed by tempol and eplerenone. In clinical study, the group with eGFR < 60 mL/min per 1.73 m2 showed significantly higher levels of urinary vanin-1 than those with eGFR≧60 mL/min per 1.73 m2.The assessmentof urinary salt excretion by spot urine showed no significant difference between these two groups.
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| Academic Significance and Societal Importance of the Research Achievements |
食塩感受性高血圧における尿細管障害の進展にROS活性を介したvanin-1の関与が明らかになった。一方、高血圧患者から採取された随時尿を用いた食塩排泄量推定値はCKDとの関連を認めなかったが、尿中vanin-1はCKDと関連することを明らかにした。本研究は新規バイオマーカーの萌芽研究として一定の意義を有するものと考える。
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