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Clinical database analysis for implementation of pharmacogenomics

Research Project

Project/Area Number 18K06782
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionShiga University of Medical Science

Principal Investigator

Terada Tomohiro  滋賀医科大学, 医学部, 客員教授 (10324641)

Co-Investigator(Kenkyū-buntansha) 池田 義人  滋賀医科大学, 医学部, 客員助教 (40736980)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords個別医療 / 医療薬学 / 遺伝子多型 / ファーマコゲノミクス検査 / 臨床データベース / 有用性検証研究
Outline of Final Research Achievements

Pharmacogenomics (PGx) test is expected to be a useful tool for realizing "Precision Medicine" in which optimal drug selection and dose adjustment are performed in accordance with individual patients.
In the present study, a PGx database linked to an electronic medical record system operated in Shiga University of Medical Science hospitals was utilized to evaluate the relationship between PGx testing results and therapeutic effects in actual clinical practice. Genetic polymorphisms of a CYP2C19 which is drug-metabolizing enzyme of clopidogrel, an antiplatelet agent, were analyzed to obtain results suggesting the utility of PGx testing in clinical practice.

Academic Significance and Societal Importance of the Research Achievements

本研究成果はファーマコゲノミクス検査に基づいた個々の患者に合わせた適切な薬剤選択・投与量決定を推進する為の基礎を担うものである。これらの成果をさらに発展させることにより、① 最適な治療効果を早急に得られることによる治療効率の向上、② 過剰投与防止に基づく有害事象発現率の低下による患者のQuality of Lifeの改善といった医学的なメリットに加え、③ 投与量の最適化による薬価負担の軽減や有害事象発現率の低減による医療費の軽減という薬剤経済学的なメリットも期待できることから、大きな社会的意義があると考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (25 results)

All 2021 2020 2019 2018

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 8 results) Presentation (12 results) (of which Int'l Joint Research: 2 results,  Invited: 6 results)

  • [Journal Article] Results of a nationwide survey of Japanese pharmacists regarding the application of pharmacogenomic testing in precision medicine2021

    • Author(s)
      Tsuji Daiki、Saito Yoshiro、Mushiroda Taisei、Miura Masatomo、Hira Daiki、Terada Tomohiro
    • Journal Title

      Journal of Clinical Pharmacy and Therapeutics

      Volume: in press Issue: 3 Pages: 649-657

    • DOI

      10.1111/jcpt.13367

    • NAID

      120006974981

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison Between Clopidogrel and Prasugrel Associated With <i>CYP2C19</i> Genotypes in Patients Receiving Percutaneous Coronary Intervention in a Japanese Population2020

    • Author(s)
      Yuichi Sawayama, Takashi Yamamoto, Yukinori Tomita, Kohei Asada, Noriaki Yagi, Megumi Fukuyama, Akashi Miyamoto, Hiroshi Sakai, Tomoya Ozawa, Tetsuichiro Isono, Daiki Hira, Tomohiro Terada, Minoru Horie, Yoshihisa Nakagawa
    • Journal Title

      Circulation Journal

      Volume: 84 Issue: 9 Pages: 1575-1581

    • DOI

      10.1253/circj.CJ-20-0254

    • NAID

      130007890783

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2020-08-25
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Investigational Study to Establish the Basic Construction of Precision Medicine from a Pharmaceutical Perspective2020

    • Author(s)
      Tsuji Daiki、Saito Yoshiro、Mushiroda Taisei、Miura Masatomo、Hira Daiki、Terada Tomohiro
    • Journal Title

      Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)

      Volume: 46 Issue: 2 Pages: 66-76

    • DOI

      10.5649/jjphcs.46.66

    • NAID

      130007983444

    • ISSN
      1346-342X, 1882-1499
    • Year and Date
      2020-02-10
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of antibiotic susceptibility and CYP3A4/5 and CYP2C19 genotype on the outcome of vonoprazan-containing Helicobacter pylori eradication therapy2020

    • Author(s)
      Sugimoto M, Hira D, Murata T, Kawai T, Terada T
    • Journal Title

      Antibiotics

      Volume: 9 Issue: 10 Pages: 645-645

    • DOI

      10.3390/antibiotics9100645

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sorafenib exposure and its correlation with response and safety in advanced hepatocellular carcinoma: results from an observational retrospective study2020

    • Author(s)
      Noda Satoshi、Hira Daiki、Osaki Rie、Fujimoto Takehide、Iida Hiroya、Tanaka-Mizuno Sachiko、Andoh Akira、Tani Masaji、Ikeda Yoshito、Morita Shin-ya、Terada Tomohiro
    • Journal Title

      Cancer Chemotherapy and Pharmacology

      Volume: 86 Issue: 1 Pages: 129-139

    • DOI

      10.1007/s00280-020-04105-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 薬学的視点に基づいたプレシジョン・メディシンの国内基盤構築のための調査研究2020

    • Author(s)
      辻大樹, 斎藤嘉朗, 莚田泰誠, 三浦昌朋, 平大樹, 寺田智祐
    • Journal Title

      医療薬学

      Volume: 46 (2) Pages: 66-76

    • NAID

      130007983444

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Personalized pharmacotherapy with sunitinib and pazopanib for Asian patients2020

    • Author(s)
      Satoshi Noda, Shin-ya Morita, Tomohiro Terada.
    • Journal Title

      J. Asian Assoc. Sch. Pharm.

      Volume: 9 Pages: 1-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exploratory Investigation of Target Pazopanib Concentration Range for Patients With Renal Cell Carcinoma2019

    • Author(s)
      Satoshi Noda, Tetsuya Yoshida, Daiki Hira, Ryosuke Murai, Keiji Tomita, Teruhiko Tsuru, Susumu Kageyama, Akihiro Kawauchi, Yoshito Ikeda, Shin-ya Morita, Tomohiro Terada.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: 17 Issue: 2 Pages: e306-e313

    • DOI

      10.1016/j.clgc.2018.12.001

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Population pharmacokinetics and pharmacodynamics of apixaban linking its plasma concentration to intrinsic activated coagulation factor X activity in Japanese patients with atrial fibrillation2019

    • Author(s)
      Ueshima Satoshi、Hira Daiki、Tomitsuka Chiho、Nomura Miki、Kimura Yuuma、Yamane Takuya、Tabuchi Yohei、Ozawa Tomoya、Itoh Hideki、Horie Minoru、Terada Tomohiro、Katsura Toshiya
    • Journal Title

      The AAPS Journal

      Volume: 21 Issue: 5 Pages: 80-80

    • DOI

      10.1208/s12248-019-0353-7

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic variants of alcohol‐metabolizing enzymes in Brugada syndrome: Insights into syncope after drinking alcohol2019

    • Author(s)
      Wu Qi、Hayashi Hideki、Hira Daiki、Sonoda Keiko、Ueshima Satoshi、Ohno Seiko、Makiyama Takeru、Terada Tomohiro、Katsura Toshiya、Miura Katsuyuki、Horie Minoru
    • Journal Title

      Journal of Arrhythmia

      Volume: 35 Issue: 5 Pages: 752-759

    • DOI

      10.1002/joa3.12227

    • NAID

      120006848263

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications.2018

    • Author(s)
      Hira D, Terada T.
    • Journal Title

      Biochem. Pharmacol.

      Volume: 147 Pages: 201-210

    • DOI

      10.1016/j.bcp.2017.10.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation.2018

    • Author(s)
      Ueshima S, Hira D, Kimura Y, Fujii R, Tomitsuka C, Yamane T, Tabuchi Y, Ozawa T, Itoh H, Ohno S, Horie M, Terada T, Katsura T.
    • Journal Title

      Br. J. Clin. Pharmacol.

      Volume: - Issue: 6 Pages: 1301-1312

    • DOI

      10.1111/bcp.13561

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oral mucositis associated with anti-EGFR therapy in colorectal cancer: single institutional retrospective cohort study2018

    • Author(s)
      Dote Satoshi、Itakura Shoji、Kamei Kohei、Hira Daiki、Noda Satoshi、Kobayashi Yuka、Terada Tomohiro
    • Journal Title

      BMC Cancer

      Volume: 18 Issue: 1 Pages: 957-957

    • DOI

      10.1186/s12885-018-4862-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] NUDT15 遺伝子多型検査測定の構築法2020

    • Author(s)
      磯野哲一郎, 平大樹, 中村吉伸, 辻徳治, 赤羽理也, 河原真大, 森田真也, 安藤朗, 寺田智祐
    • Organizer
      第30回日本医療薬学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 心房細動患者におけるエドキサバンの母集団薬物動態/ゲノム薬理学的解析2020

    • Author(s)
      上島智, 平大樹, 道籏梨央, 田淵陽平, 伊藤英樹, 小澤友哉, 中川義久, 堀江稔, 寺田智祐, 桂敏也
    • Organizer
      第30回日本医療薬学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肝細胞がん患者におけるソラフェニブの血中濃度と治療効果・副作用の関連2020

    • Author(s)
      野田哲史, 平大樹, 大﨑理英, 藤本剛英, 飯田洋也, 田中佐智子, 安藤朗, 谷眞至, 池田義人, 森田真也, 寺田智祐
    • Organizer
      第41回日本臨床薬理学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 薬学的視点に基づいたプレシジョン・メディシン~現状と展望~2019

    • Author(s)
      寺田智祐, 平大樹
    • Organizer
      日本薬剤学会第34年会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 臨床化学・薬学的視点に基づいたゲノムサイエンスの臨床実装2019

    • Author(s)
      寺田智祐
    • Organizer
      第59回日本臨床化学会年次学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] がんゲノム医療元年~薬剤師として何ができるのか~2019

    • Author(s)
      寺田智祐
    • Organizer
      第29回日本医療薬学会年会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 実臨床におけるファーマコゲノミクス検査の活用状況2019

    • Author(s)
      平大樹, 辻大樹, 齋藤嘉朗, 莚田泰誠, 三浦昌朋, 寺田智祐
    • Organizer
      第29回日本医療薬学会年会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] PK/PD/PGx analysis of tyrosine kinase inhibitors ~from research to practice2019

    • Author(s)
      Tomohiro Terada
    • Organizer
      The 9th Asian Association of Schools of Pharmacy (AASP) Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Tyrosine kinase inhibitors and PGx of ABCG22019

    • Author(s)
      Tomohiro Terada
    • Organizer
      17th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology (IATDMCT)
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] ファーマコゲノミクス検査の臨床実装2018

    • Author(s)
      寺田 智祐, 平 大樹
    • Organizer
      第35回日本TDM学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] ファーマコゲノミクス検査に基づいた抗血小板薬選択の実態調査(優秀発表賞受賞)2018

    • Author(s)
      磯野哲一郎, 平 大樹, 福井里佳, 田淵陽平, 赤羽理也, 池田義人, 森田真也, 寺田智祐
    • Organizer
      第35回日本TDM学会学術大会
    • Related Report
      2018 Research-status Report
  • [Presentation] 薬物代謝酵素の遺伝子多型測定に基づくトラマドールの個別化投与設計2018

    • Author(s)
      平 大樹, 岩下成人, 神谷貴樹, 中島 亮, 磯野哲一郎, 赤羽理也, 池田義人, 角本幹夫, 森田真也, 岡野友信, 今井晋二, 福井 聖, 寺 田智祐
    • Organizer
      第40回 日本疼痛学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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