The development of a novel mucosal vaccine system using NO donors
| Project/Area Number |
18K06798
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 47060:Clinical pharmacy-related
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
TADA RUI 東京薬科大学, 薬学部, 講師 (70635888)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 粘膜ワクチン / 一酸化窒素 / タイトジャンクション / 抗原送達 / 抗原デリバリー / 感染症 / DDS / 抗原 / デリバリーシステム / 肺炎球菌 |
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| Outline of Final Research Achievements |
Mucosal vaccine is widely considered as next-generation vaccines to combat infectious diseases. However, there are no subunit-type mucosal vaccines in clinical settings. Therefore, we aimed to develop a mucosal vaccine system using a nitric oxide donor. In this study, we found that intranasal administration of a nitric oxide donor in combination with an antigenic protein potentiated antigen-specific both mucosal IgA and systemic IgG. Furthermore, this system was considered to be safe, as inflammatory reactions and weight loss were not observed.
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| Academic Significance and Societal Importance of the Research Achievements |
新型コロナウイルスのパンデミックは人類の感染症に対する脆弱さを痛感させた。生命のみならず社会秩序および経済を守るためには効果的な粘膜ワクチンの開発が必要不可欠であると思われる。本研究により見いだされた一酸化窒素供与体を用いたサブユニット型の粘膜ワクチンシステムは、粘膜ワクチンの新しいモダリティとなり得ると考えられた。さらなる研究開発によって多くのワクチンモダリティの一翼を担うことで社会に貢献することが期待される。
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Enzymatically polymerised polyphenols prepared from various precursors potentiate antigen-specific immune responses in both mucosal and systemic compartments in mice2021
Author(s)
Tada, R., Ogasawara, M., Yamanaka, D., Sakurai, Y., Negishi, Y., Kiyono, H., Ohno, N., Kunisawa, J. and Aramaki, Y.
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Journal Title
PLoS One
Volume: eCollection 16(2)
Issue: 2
Pages: e0246422-e0246422
DOI
Related Report
Peer Reviewed / Open Access
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