| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The mechanism of onset and exacerbation of IgA nephropathy has not been fully understood. Mannan-binding protein (MBP) is a molecule of innate immunity, excluding pathogen through the binding to oligosaccharides having mannose residue on their terminus. Several clinical findings that suggest MBP might be involved in the onset and exacerbation of IgA nephropathy have been reported. In this research, we tested the hypothesis that MBP plays an role in the onset and exacerbation of IgA nephropathy through the binding to oligomannose-type glycans of IgA and the activating complement. As a result, tendency of increasement of hematuria has been found in the mice after administration of IgA having oligomannose-type glycans. This result suggests MBP plays an role in the onset and exacerbation of IgA nephropathy.
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